Innate lymphoid cells in antitumor immunity.

Détails

ID Serval
serval:BIB_F4D2A841BA31
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Innate lymphoid cells in antitumor immunity.
Périodique
Journal of leukocyte biology
Auteur⸱e⸱s
Salomé B., Jandus C.
ISSN
1938-3673 (Electronic)
ISSN-L
0741-5400
Statut éditorial
Publié
Date de publication
03/2018
Peer-reviewed
Oui
Volume
103
Numéro
3
Pages
479-483
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Innate lymphoid cells (ILCs) are the most recently characterized subset of innate lymphocytes. Based on their specific transcriptional regulation, cytokine secretion pattern and effector functions ILCs mirror the different CD4 T helper cell subsets, with the unique attributes of acting locally in early phases of immune responses, in an antigen-independent manner. In this review, we discuss how ILCs have been implicated in tumorigenesis. Their presence might favor or inhibit tumor growth, depending on the cytokines released and the specific tumor microenvironment. As our understanding of ILCs' contribution to antitumor responses advances, clinical options to target ILCs in antitumor therapies are also emerging.
Mots-clé
Animals, Humans, Immunity, Innate/immunology, Inflammation/immunology, Lymphocytes/immunology, Neoplasms/immunology, Innate, cancer, cell subsets, cytokines
Pubmed
Web of science
Création de la notice
27/01/2018 13:22
Dernière modification de la notice
20/08/2019 16:21
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