Synaptic processes and immune-related pathways implicated in Tourette syndrome.

Détails

Ressource 1Télécharger: Paschou_s41398-020-01082-z.pdf (1302.97 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_F4282F0490A3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Synaptic processes and immune-related pathways implicated in Tourette syndrome.
Périodique
Translational psychiatry
Auteur⸱e⸱s
Tsetsos F., Yu D., Sul J.H., Huang A.Y., Illmann C., Osiecki L., Darrow S.M., Hirschtritt M.E., Greenberg E., Muller-Vahl K.R., Stuhrmann M., Dion Y., Rouleau G.A., Aschauer H., Stamenkovic M., Schlögelhofer M., Sandor P., Barr C.L., Grados M.A., Singer H.S., Nöthen M.M., Hebebrand J., Hinney A., King R.A., Fernandez T.V., Barta C., Tarnok Z., Nagy P., Depienne C., Worbe Y., Hartmann A., Budman C.L., Rizzo R., Lyon G.J., McMahon W.M., Batterson J.R., Cath D.C., Malaty I.A., Okun M.S., Berlin C., Woods D.W., Lee P.C., Jankovic J., Robertson M.M., Gilbert D.L., Brown L.W., Coffey B.J., Dietrich A., Hoekstra P.J., Kuperman S., Zinner S.H., Wagner M., Knowles J.A., Jeremy Willsey A., Tischfield J.A., Heiman G.A., Cox N.J., Freimer N.B., Neale B.M., Davis L.K., Coppola G., Mathews C.A., Scharf J.M., Paschou P., Barr C.L., Batterson J.R., Berlin C., Budman C.L., Cath D.C., Coppola G., Cox N.J., Darrow S., Davis L.K., Dion Y., Freimer N.B., Grados M.A., Greenberg E., Hirschtritt M.E., Huang A.Y., Illmann C., King R.A., Kurlan R., Leckman J.F., Lyon G.J., Malaty I.A., Mathews C.A., McMahon W.M., Neale B.M., Okun M.S., Osiecki L., Robertson M.M., Rouleau G.A., Sandor P., Scharf J.M., Singer H.S., Smit J.H., Sul J.H., Yu D., Aschauer HAH, Barta C., Budman C.L., Cath D.C., Depienne C., Hartmann A., Hebebrand J., Konstantinidis A., Mathews C.A., Müller-Vahl K., Nagy P., Nöthen M.M., Paschou P., Rizzo R., Rouleau G.A., Sandor P., Scharf J.M., Schlögelhofer M., Stamenkovic M., Stuhrmann M., Tsetsos F., Tarnok Z., Wolanczyk T., Worbe Y., Brown L., Cheon K.A., Coffey B.J., Dietrich A., Fernandez T.V., Garcia-Delgar B., Gilbert D., Grice D.E., Hagstrøm J., Hedderly T., Heiman G.A., Heyman I., Hoekstra P.J., Huyser C., Kim Y.K., Kim Y.S., King R.A., Koh Y.J., Kook S., Kuperman S., Leventhal B.L., Madruga-Garrido M., Mir P., Morer A., Münchau A., Plessen K.J., Roessner V., Shin E.Y., Song D.H., Song J., Tischfield J.A., Willsey A.J., Zinner S., Aschauer H., Barr C.L., Barta C., Batterson J.R., Berlin C., Brown L., Budman C.L., Cath D.C., Coffey B.J., Coppola G., Cox N.J., Darrow S., Davis L.K., Depienne C., Dietrich A., Dion Y., Fernandez T., Freimer N.B., Gilbert D., Grados M.A., Greenberg E., Hartmann A., Hebebrand J., Heiman G., Hirschtritt M.E., Hoekstra P., Huang A.Y., Illmann C., Jankovic J., King R.A., Kuperman S., Lee P.C., Lyon G.J., Malaty I.A., Mathews C.A., McMahon W.M., Müller-Vahl K., Nagy P., Neale B.M., Nöthen M.M., Okun M.S., Osiecki L., Paschou P., Rizzo R., Robertson M.M., Rouleau G.A., Sandor P., Scharf J.M., Schlögelhofer M., Singer H.S., Stamenkovic M., Stuhrmann M., Sul J.H., Tarnok Z., Tischfield J., Tsetsos F., Willsey A.J., Woods D., Worbe Y., Yu D., Zinner S.
Collaborateur⸱rice⸱s
Tourette Association of America International Consortium for Genetics, Gilles de la Tourette GWAS Replication Initiative, Tourette International Collaborative Genetics Study, Psychiatric Genomics Consortium Tourette Syndrome Working Group
ISSN
2158-3188 (Electronic)
ISSN-L
2158-3188
Statut éditorial
Publié
Date de publication
18/01/2021
Peer-reviewed
Oui
Volume
11
Numéro
1
Pages
56
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural
Publication Status: epublish
Résumé
Tourette syndrome (TS) is a neuropsychiatric disorder of complex genetic architecture involving multiple interacting genes. Here, we sought to elucidate the pathways that underlie the neurobiology of the disorder through genome-wide analysis. We analyzed genome-wide genotypic data of 3581 individuals with TS and 7682 ancestry-matched controls and investigated associations of TS with sets of genes that are expressed in particular cell types and operate in specific neuronal and glial functions. We employed a self-contained, set-based association method (SBA) as well as a competitive gene set method (MAGMA) using individual-level genotype data to perform a comprehensive investigation of the biological background of TS. Our SBA analysis identified three significant gene sets after Bonferroni correction, implicating ligand-gated ion channel signaling, lymphocytic, and cell adhesion and transsynaptic signaling processes. MAGMA analysis further supported the involvement of the cell adhesion and trans-synaptic signaling gene set. The lymphocytic gene set was driven by variants in FLT3, raising an intriguing hypothesis for the involvement of a neuroinflammatory element in TS pathogenesis. The indications of involvement of ligand-gated ion channel signaling reinforce the role of GABA in TS, while the association of cell adhesion and trans-synaptic signaling gene set provides additional support for the role of adhesion molecules in neuropsychiatric disorders. This study reinforces previous findings but also provides new insights into the neurobiology of TS.
Pubmed
Web of science
Open Access
Oui
Création de la notice
26/01/2021 13:31
Dernière modification de la notice
23/02/2021 7:11
Données d'usage