Clinical experience with adalimumab in a multicenter Swiss cohort of patients with Crohn's disease : P132

Détails

ID Serval
serval:BIB_F3A9E1D2CA22
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Poster: résume de manière illustrée et sur une page unique les résultats d'un projet de recherche. Les résumés de poster doivent être entrés sous "Abstract" et non "Poster".
Collection
Publications
Institution
Titre
Clinical experience with adalimumab in a multicenter Swiss cohort of patients with Crohn's disease : P132
Titre de la conférence
4th Congress of ECCO (the European Crohn's and Colitis Organization)
Auteur(s)
Nichita C.M., Stelle M., Vavricka S., El-Wafa A., Ballabeni P., de Saussure P., Straumann A., Rogler G., Michetti P.
Adresse
Hamburg, Germany, February 5-7, 2009
ISBN
1873-9946[electronic]
Statut éditorial
Publié
Date de publication
2009
Volume
3
Série
Journal of Crohn's and Colitis
Pages
S63
Langue
anglais
Notes
Background: Adalimumab (ADA) is a fully human monoclonal
antibody which binds with a high affinity and specificity to
tumor necrosis factor (TNFa). Controlled clinical trials have
demonstrated its efficacy and safety in the treatment of
moderate-to-severe Crohn's disease (CD). However, long term
experience with ADA in real-life clinical practice has rarely
been reported.
Objective: to assess the long term effectiveness and the safety
of ADA in a multicenter cohort of patients with moderate-tosevere
CD.
Methods: Fifty-five patients (21 men, 34 women), mean
age 37.5 years (±11.4 years), median disease duration
12.7 years (range 1 41 years) were treated with ADA and
followed up over a period of 52 weeks (range 12 96 weeks,
median 50 weeks). Thirty-eight patients had previously been
treated with infliximab (IFX). The ADA induction regimen was
160/80 mg in 31 patients and 80/40 mg in 24 patients. The
clinical evolution during treatment was evaluated with the
Harvey Bradshaw Index (HBI) at week (W) 4 6, 12, 24 and 52.
Patients were classified in three categories: remission (HBI < 4
pts), response (reduction HBI >3 pts) and non response.
Results: On week 4 6, a response was demonstrated in 83.6 %
patients and remission was obtained in 52.7%. The remission
was maintained in 89.6% and 72.4% of the patients at W12
and W24, respectively. In per protocol analysis at W52, half
of patients were still in response and half had stopped ADA:
5/19 because of adverse events and 14/19 because of no
response or loss of response. Thirteen patients (23.6%) needed
a dose escalation after a mean interval of 7 months (range
1 24 month). The response rate at W4 6 was not influenced
by gender, smoking status, disease duration, localisation of
disease, previous surgery, previous IFX treatment, the first
month total ADA dose, or the first month ADA dose divided
by body weight. Interestingly, however, the remission rate at
W4 6 was significantly higher in patients intolerant (78.9%) to
IFX, as compared to those who had lost response to IFX (42.1%;
p = 0.02). Overall ADA was well tolerated, 54.5% patients didn't
report any side effects. The most common side effect was pain
at the injection site (10.9%), followed by asthenia (9%) and
infections (7.2%).
Conclusion: ADA was effective and safe in clinical practice as
induction and maintenance therapy for patients with moderateto-
severe CD.
Open Access
Oui
Création de la notice
28/01/2010 9:27
Dernière modification de la notice
20/08/2019 16:20
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