3D genomics across the tree of life reveals condensin II as a determinant of architecture type.

Détails

ID Serval
serval:BIB_F39016606761
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
3D genomics across the tree of life reveals condensin II as a determinant of architecture type.
Périodique
Science
Auteur⸱e⸱s
Hoencamp C., Dudchenko O., Elbatsh AMO, Brahmachari S., Raaijmakers J.A., van Schaik T., Sedeño Cacciatore Á., Contessoto V.G., van Heesbeen RGHP, van den Broek B., Mhaskar A.N., Teunissen H., St Hilaire B.G., Weisz D., Omer A.D., Pham M., Colaric Z., Yang Z., Rao SSP, Mitra N., Lui C., Yao W., Khan R., Moroz L.L., Kohn A., St Leger J., Mena A., Holcroft K., Gambetta M.C., Lim F., Farley E., Stein N., Haddad A., Chauss D., Mutlu A.S., Wang M.C., Young N.D., Hildebrandt E., Cheng H.H., Knight C.J., Burnham TLU, Hovel K.A., Beel A.J., Mattei P.J., Kornberg R.D., Warren W.C., Cary G., Gómez-Skarmeta J.L., Hinman V., Lindblad-Toh K., Di Palma F., Maeshima K., Multani A.S., Pathak S., Nel-Themaat L., Behringer R.R., Kaur P., Medema R.H., van Steensel B., de Wit E., Onuchic J.N., Di Pierro M., Lieberman Aiden E., Rowland B.D.
ISSN
1095-9203 (Electronic)
ISSN-L
0036-8075
Statut éditorial
Publié
Date de publication
28/05/2021
Peer-reviewed
Oui
Volume
372
Numéro
6545
Pages
984-989
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
Publication Status: ppublish
Résumé
We investigated genome folding across the eukaryotic tree of life. We find two types of three-dimensional (3D) genome architectures at the chromosome scale. Each type appears and disappears repeatedly during eukaryotic evolution. The type of genome architecture that an organism exhibits correlates with the absence of condensin II subunits. Moreover, condensin II depletion converts the architecture of the human genome to a state resembling that seen in organisms such as fungi or mosquitoes. In this state, centromeres cluster together at nucleoli, and heterochromatin domains merge. We propose a physical model in which lengthwise compaction of chromosomes by condensin II during mitosis determines chromosome-scale genome architecture, with effects that are retained during the subsequent interphase. This mechanism likely has been conserved since the last common ancestor of all eukaryotes.
Mots-clé
Adenosine Triphosphatases/chemistry, Adenosine Triphosphatases/genetics, Adenosine Triphosphatases/physiology, Algorithms, Animals, Biological Evolution, Cell Nucleolus/ultrastructure, Cell Nucleus/ultrastructure, Centromere/ultrastructure, Chromosomes/chemistry, Chromosomes/ultrastructure, Chromosomes, Human/chemistry, Chromosomes, Human/ultrastructure, DNA-Binding Proteins/chemistry, DNA-Binding Proteins/genetics, DNA-Binding Proteins/physiology, Eukaryota/genetics, Genome, Genome, Human, Genomics, Heterochromatin/ultrastructure, Humans, Interphase, Mitosis, Models, Biological, Multiprotein Complexes/chemistry, Multiprotein Complexes/genetics, Multiprotein Complexes/physiology, Telomere/ultrastructure
Pubmed
Web of science
Financement(s)
Conseil Européen de la Recherche (ERC)
Création de la notice
31/05/2021 13:04
Dernière modification de la notice
10/07/2021 5:33
Données d'usage