p21ras supports the survival of chick embryonic motor neurones.

Détails

ID Serval
serval:BIB_F30513440827
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
p21ras supports the survival of chick embryonic motor neurones.
Périodique
Neuroreport
Auteur⸱e⸱s
Weng G., Markus M.A., Markus A., Winkler A., Borasio G.D.
ISSN
0959-4965 (Print)
ISSN-L
0959-4965
Statut éditorial
Publié
Date de publication
1996
Volume
7
Numéro
5
Pages
1077-1081
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Various trophic factors present in muscle extract can promote the survival of cultured motor neurones. However, little is known about the signal transduction pathways used in these cells. The proto-oncogene product p21ras has been shown to play an important role in proliferative and differentiative signalling pathways. We report here that cytoplasmic introduction of its oncogenic form, p21ras(G12V), fully supports the in vitro survival of chick embryonic motor neurones. The proto-oncogenic form of p21ras also showed a dose-dependent survival effect, while a C-terminally truncated counterpart of p21ras(G12V) was ineffective. These results suggest an involvement of p21ras in signal transduction pathways leading to motor neurone survival and may be of relevance for the development of therapeutic strategies for motor neurone disease.
Mots-clé
Animals, Cell Survival/drug effects, Cells, Cultured, Chick Embryo, Cytoplasm/drug effects, Microinjections, Motor Neurons/cytology, Motor Neurons/drug effects, Nerve Growth Factors/pharmacology, Proto-Oncogene Proteins p21(ras)/pharmacology, Reducing Agents, Signal Transduction/drug effects
Pubmed
Création de la notice
13/01/2014 17:49
Dernière modification de la notice
20/08/2019 17:20
Données d'usage