CMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathology

Détails

ID Serval
serval:BIB_F2F8B065B822
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
CMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathology
Périodique
Nature Immunology
Auteur⸱e⸱s
Knizkova Daniela, Pribikova Michaela, Draberova Helena, Semberova Tereza, Trivic Tijana, Synackova Alzbeta, Ujevic Andrea, Stefanovic Jana, Drobek Ales, Huranova Martina, Niederlova Veronika, Tsyklauri Oksana, Neuwirth Ales, Tureckova Jolana, Stepanek Ondrej, Draber Peter
ISSN
1529-2908
1529-2916
Statut éditorial
Publié
Date de publication
11/2022
Peer-reviewed
Oui
Volume
23
Numéro
11
Pages
1644-1652
Langue
anglais
Résumé
Interleukin-17A (IL-17A) is a key mediator of protective immunity to yeast and bacterial infections but also drives the pathogenesis of several autoimmune diseases, such as psoriasis or psoriatic arthritis. Here we show that the tetra-transmembrane protein CMTM4 is a subunit of the IL-17 receptor (IL-17R). CMTM4 constitutively associated with IL-17R subunit C to mediate its stability, glycosylation and plasma membrane localization. Both mouse and human cell lines deficient in CMTM4 were largely unresponsive to IL-17A, due to their inability to assemble the IL-17R signaling complex. Accordingly, CMTM4-deficient mice had a severe defect in the recruitment of immune cells following IL-17A administration and were largely resistant to experimental psoriasis, but not to experimental autoimmune encephalomyelitis. Collectively, our data identified CMTM4 as an essential component of IL-17R and a potential therapeutic target for treating IL-17-mediated autoimmune diseases.
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/02/2024 14:59
Dernière modification de la notice
03/01/2025 16:24
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