Transvaginal progesterone: evidence for a new functional 'portal system' flowing from the vagina to the uterus

Détails

ID Serval
serval:BIB_F2328C4AD853
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Transvaginal progesterone: evidence for a new functional 'portal system' flowing from the vagina to the uterus
Périodique
Human Reproduction Update
Auteur⸱e⸱s
Cicinelli  E., de Ziegler  D.
ISSN
1355-4786
Statut éditorial
Publié
Date de publication
08/1999
Peer-reviewed
Oui
Volume
5
Numéro
4
Pages
365-72
Notes
Journal Article
Review --- Old month value: Jul-Aug
Résumé
The results of many recent experimental and clinical studies support the hypothesis that progesterone administered vaginally is distributed selectively to the uterus where tissue concentrations and effects exceed expectations. This phenomenon has multiple clinical implications in several fields of gynaecological endocrinology, notably in assisted reproductive treatments and new forms of hormone replacement therapy. Yet, the actual mechanisms by which vaginal administration of progesterone can induce higher concentrations in the uterus, despite low concentrations in the systemic circulation, remain obscure and most puzzling to many gynaecologists. This review aims to muster ideas and propose different mechanisms to explain the observed phenomenon. In particular, we will summarize data that support the various putative modes of transport including, direct diffusion through tissue, intracervical aspiration, absorption into the venous or lymphatic circulatory systems and countercurrent vascular exchange with diffusion from utero-vaginal veins/lymph vessels to arteries. All these mechanisms may concur to various extents to the uterine specificity of vaginal progesterone.
Mots-clé
Administration, Intravaginal Animals Female Hormone Replacement Therapy Humans Lymphatic System Progesterone/*administration & dosage/*pharmacokinetics Uterus/blood supply/*metabolism Vagina/blood supply/*metabolism Veins
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/02/2008 11:37
Dernière modification de la notice
20/08/2019 16:19
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