Human "T<sub>H</sub>9" cells are a subpopulation of PPAR-γ<sup>+</sup> T<sub>H</sub>2 cells.

Détails

ID Serval
serval:BIB_F1E6E4C16DDC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Human "T<sub>H</sub>9" cells are a subpopulation of PPAR-γ<sup>+</sup> T<sub>H</sub>2 cells.
Périodique
Science immunology
Auteur(s)
Micossé C., von Meyenn L., Steck O., Kipfer E., Adam C., Simillion C., Seyed Jafari S.M., Olah P., Yawlkar N., Simon D., Borradori L., Kuchen S., Yerly D., Homey B., Conrad C., Snijder B., Schmidt M., Schlapbach C.
ISSN
2470-9468 (Electronic)
ISSN-L
2470-9468
Statut éditorial
Publié
Date de publication
18/01/2019
Peer-reviewed
Oui
Volume
4
Numéro
31
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Although T <sub>H</sub> 1, T <sub>H</sub> 2, and T <sub>H</sub> 17 cells are well-defined T <sub>H</sub> cell lineages in humans, it remains debated whether IL-9-producing T <sub>H</sub> cells represent a bona fide "T <sub>H</sub> 9" lineage. Our understanding of the cellular characteristics and functions of IL-9-producing T <sub>H</sub> cells in humans is still nascent. Here, we report that human IL-9-producing T <sub>H</sub> cells express the chemokine receptors CCR4 and CCR8, produce high levels of IL-5 and IL-13, and express T <sub>H</sub> 2 lineage-associated transcription factors. In these cells, IL-9 production is activation dependent, transient, and accompanied by down-regulation of T <sub>H</sub> 2 cytokines, leading to an apparent "T <sub>H</sub> 9" phenotype. IL-9 <sup>+</sup> T <sub>H</sub> 2 cells can be distinguished from "conventional" T <sub>H</sub> 2 cells based on their expression of the transcription factor PPAR-γ. Accordingly, PPAR-γ is induced in naïve T <sub>H</sub> cells by priming with IL-4 and TGF-β ("T <sub>H</sub> 9" priming) and is required for IL-9 production. In line with their identity as early activated T <sub>H</sub> 2 cells, IL-9 <sup>+</sup> T <sub>H</sub> 2 cells are found in acute allergic skin inflammation in humans. We propose that IL-9-producing T <sub>H</sub> cells are a phenotypically and functionally distinct subpopulation of T <sub>H</sub> 2 cells that depend on PPAR-γ for full effector functions.
Mots-clé
Cytokines/immunology, Cytokines/metabolism, Dermatitis, Allergic Contact/immunology, Dermatitis, Atopic/immunology, Humans, PPAR gamma/immunology, PPAR gamma/metabolism, Psoriasis/immunology, Th2 Cells/cytology, Th2 Cells/immunology, Th2 Cells/metabolism
Pubmed
Web of science
Création de la notice
18/02/2019 12:01
Dernière modification de la notice
27/04/2020 6:20
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