Consequences of gestational stress on GABAergic modulation of respiratory activity in developing newborn pups.

Détails

ID Serval
serval:BIB_F1B596F928ED
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Consequences of gestational stress on GABAergic modulation of respiratory activity in developing newborn pups.
Périodique
Respiratory Physiology and Neurobiology
Auteur(s)
Delhaes F., Fournier S., Tolsa J.F., Peyter A.C., Bairam A., Kinkead R.
ISSN
1878-1519 (Electronic)
ISSN-L
1569-9048
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
200
Pages
72-79
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
The GABAergic system modulates respiratory activity and undergoes substantial changes during early life. Because this maturation process is sensitive to stress, we tested the hypothesis that gestational stress (GS) alters development of GABAergic modulation of respiratory control in rat pups. The respiratory responses to the selective GABAA receptor agonist muscimol were compared between pups born to dams subjected to GS (bright light and predator odor; 20 min/day from G9 to G19) or maintained under standard (control) conditions. Respiratory activity was measured on 1 and 4 days old pups of both sexes using in vivo (whole body plethysmography) and in vitro (isolated brainstem-spinal cord preparation) approaches. In intact pups, muscimol injection (0.75 mg/kg; i.p.) depressed minute ventilation; this response was less in GS pups, and at P4, muscimol augmented minute ventilation in GS females. Bath application of muscimol (0.01-0.5 μM) onto brainstem preparations decreased inspiratory (C4) burst frequency and amplitude in a dose-dependent manner; the responsiveness decreased with age. However, GS had limited effects on these results. We conclude that the results obtained in vivo are consistent with our hypothesis and show that GS delays maturation of GABAergic modulation of respiratory activity. The differences in the results observed between experimental approaches (in vivo versus in vitro) indicate that the effect of prenatal stress on maturation of GABAergic modulation of respiratory control mainly affects the peripheral/metabolic components of the respiratory control system.
Pubmed
Web of science
Création de la notice
05/09/2014 18:06
Dernière modification de la notice
20/08/2019 17:19
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