Sex steroid regulation of the hypothalamo-pituitary-adrenal axis activity in middle-aged mice during endotoxic shock
Détails
ID Serval
serval:BIB_F134AFBC9B18
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Sex steroid regulation of the hypothalamo-pituitary-adrenal axis activity in middle-aged mice during endotoxic shock
Périodique
Neuroimmunomodulation
ISSN
1021-7401 (Print)
Statut éditorial
Publié
Date de publication
10/1994
Volume
1
Numéro
5
Pages
315-20
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep-Oct
Research Support, Non-U.S. Gov't --- Old month value: Sep-Oct
Résumé
Many studies have documented the presence of a sexually dimorphic response of neuroendocrine functions in response to immune signals. The aims of the present study were to evaluate the hypothalamopituitary-adrenal (HPA) axis response to inflammatory stress stimulus in 15-month-old mice, and to determine whether such a response depends on circulating sex steroids. Our results indicate that in the 15-month-old mice: (1) there is a sexual dimorphism in the HPA axis activity in basal condition and after endotoxin treatment with generally higher levels of several parameters of this axis in female than in male mice, (2) gonadectomy alone, followed by sex steroid therapy, modulates HPA axis function in both basal and stress conditions, and (3) whereas estradiol plays a stimulatory role on adrenal function, testosterone inhibits adrenal glucocorticoid production. This study further suggests a clear sexual dimorphism in middle-aged mice injected with endotoxin. These results may be relevant for the treatment of sepsis in aged patients.
Mots-clé
Adrenal Cortex/*immunology
Adrenocorticotropic Hormone/blood
Animals
Corticosterone/blood
Endotoxins/*pharmacology
Female
Gonadal Steroid Hormones/*pharmacology
Hypothalamo-Hypophyseal System/*immunology
Inflammation
Male
Mice
Mice, Inbred BALB C
Stress
Time Factors
Pubmed
Création de la notice
15/02/2008 17:58
Dernière modification de la notice
20/08/2019 17:18