Developmental constraints on vertebrate genome evolution.

Détails

Ressource 1Télécharger: BIB_F11302BD61EC.P001.pdf (457.83 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_F11302BD61EC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Developmental constraints on vertebrate genome evolution.
Périodique
PLoS Genetics
Auteur(s)
Roux J., Robinson-Rechavi M.
ISSN
1553-7404 (Electronic)
ISSN-L
1553-7390
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
4
Numéro
12
Pages
e1000311
Langue
anglais
Résumé
Constraints in embryonic development are thought to bias the direction of evolution by making some changes less likely, and others more likely, depending on their consequences on ontogeny. Here, we characterize the constraints acting on genome evolution in vertebrates. We used gene expression data from two vertebrates: zebrafish, using a microarray experiment spanning 14 stages of development, and mouse, using EST counts for 26 stages of development. We show that, in both species, genes expressed early in development (1) have a more dramatic effect of knock-out or mutation and (2) are more likely to revert to single copy after whole genome duplication, relative to genes expressed late. This supports high constraints on early stages of vertebrate development, making them less open to innovations (gene gain or gene loss). Results are robust to different sources of data -- gene expression from microarrays, ESTs, or in situ hybridizations; and mutants from directed KO, transgenic insertions, point mutations, or morpholinos. We determine the pattern of these constraints, which differs from the model used to describe vertebrate morphological conservation ("hourglass" model). While morphological constraints reach a maximum at mid-development (the "phylotypic" stage), genomic constraints appear to decrease in a monotonous manner over developmental time.
Mots-clé
Animals, Evolution, Molecular, Expressed Sequence Tags, Gene Duplication, Gene Expression Regulation, Developmental, Genome, Mice/embryology, Mice/genetics, Zebrafish/embryology, Zebrafish/genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/11/2008 11:36
Dernière modification de la notice
20/08/2019 17:18
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