Absence of fatty acid transporter CD36 protects against Western-type diet-related cardiac dysfunction following pressure overload in mice.

Détails

ID Serval
serval:BIB_F0E00542C565
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Absence of fatty acid transporter CD36 protects against Western-type diet-related cardiac dysfunction following pressure overload in mice.
Périodique
American Journal of Physiology. Endocrinology and Metabolism
Auteur⸱e⸱s
Steinbusch L.K., Luiken J.J., Vlasblom R., Chabowski A., Hoebers N.T., Coumans W.A., Vroegrijk I.O., Voshol P.J., Ouwens D.M., Glatz J.F., Diamant M.
ISSN
1522-1555 (Electronic)
ISSN-L
0193-1849
Statut éditorial
Publié
Date de publication
2011
Volume
301
Numéro
4
Pages
E618-E627
Langue
anglais
Résumé
Cardiac patients often are obese and have hypertension, but in most studies these conditions are investigated separately. Here, we aimed at 1) elucidating the interaction of metabolic and mechanophysical stress in the development of cardiac dysfunction in mice and 2) preventing this interaction by ablation of the fatty acid transporter CD36. Male wild-type (WT) C57Bl/6 mice and CD36(-/-) mice received chow or Western-type diet (WTD) for 10 wk and then underwent a sham surgery or transverse aortic constriction (TAC) under anesthesia. After a 6-wk continuation of the diet, cardiac function, morphology, lipid profiles, and molecular parameters were assessed. WTD administration affected body and organ weights of WT and CD36(-/-) mice, but it affected only plasma glucose and insulin concentrations in WT mice. Cardiac lipid concentrations increased in WT mice receiving WTD, decreased in CD36(-/-) on chow, and remained unchanged in CD36(-/-) receiving WTD. TAC induced cardiac hypertrophy in WT mice on chow but did not affect cardiac function and cardiac lipid concentrations. WTD or CD36 ablation worsened the outcome of TAC. Ablation of CD36 protected against the WTD-related aggravation of cardiac functional and structural changes induced by TAC. In conclusion, cardiac dysfunction and remodeling worsen when the heart is exposed to two stresses, metabolic and mechanophysical, at the same time. CD36 ablation prevents the metabolic stress resulting from a WTD. Thus, metabolic conditions are a critical factor for the compromised heart and provide new targets for metabolic manipulation in cardioprotection.
Mots-clé
Animals, Antigens, CD36/genetics, Antigens, CD36/metabolism, Aortic Valve Stenosis/complications, Blood Glucose/metabolism, Cardiomegaly/etiology, Cardiomegaly/metabolism, Diet, Heart/physiopathology, Male, Mice, Mice, Knockout, Myocardium/metabolism, Myocardium/pathology, Obesity/complications
Pubmed
Web of science
Création de la notice
18/07/2013 10:20
Dernière modification de la notice
20/08/2019 16:18
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