Nociplastic pain and associated non-pain symptoms are frequent health issues in primary care. Professionals may feel apprehensive about their management and face challenges due to the complexity and chronicity of the somatopsychic conditions. A thorough understanding of nociplastic mechanisms, associated clinical elements, and the biopsychosocial model are necessary for individualized evaluation, identifying affected patients, selecting dedicated treatments to desensitize the central nervous system, and building a solid partnership between the patient and the clinician.