Premature atherosclerosis in patients with xanthelasma.

Détails

ID Serval
serval:BIB_EF8C01F79577
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Premature atherosclerosis in patients with xanthelasma.
Périodique
Journal of the European Academy of Dermatology and Venereology
Auteur(s)
Noël B.
ISSN
0926-9959 (Print)
ISSN-L
0926-9959
Statut éditorial
Publié
Date de publication
10/2007
Peer-reviewed
Oui
Volume
21
Numéro
9
Pages
1244-1248
Langue
anglais
Notes
Publication types: Journal Article
Résumé
BACKGROUND: Only about half the patients with xanthelasma are hyperlipidemic. The clinical significance of xanthelasma as a marker of cardiovascular disease is not yet well defined.
OBJECTIVE: To determine the risk of cardiovascular disease in patients with normolipidemic and hyperlipidemic xanthelasma.
METHODS: Carotid ultrasonography (7 MHz using B-mode images, Advanced Technology Laboratories) was used to detect carotid plaques and measure the intima-media thickness (IMT) of the common carotid arteries. Seventeen patients with normolipidemic and hyperlipidemic xanthelasma were examined and compared with 21 age-matched normal subjects.
RESULTS: The risk of cardiovascular disease was significantly increased in patients with xanthelasma. Carotid plaques were more frequent in patients with xanthelasma than in controls (64.7% and 23.8%, respectively; P = 0.020), and IMT was significantly higher (mean +/- SD: 1.1 +/- 0.1 and 0.6 +/- 0.2 mm, respectively; P < 0.001). The difference of carotid IMT between normolipidemic xanthelasma and hyperlipidemic xanthelasma was not statistically different (mean +/- SD: 1.1 +/- 0.1 and 1.1 +/- 0.2 mm, respectively; P = 0.577).
CONCLUSION: Premature carotid atherosclerosis is observed in patients with normolipidemic and hyperlipidemic xanthelasma. Patients with xanthelasma should be considered to have an increased risk of cardiovascular disease independently to the level of plasma lipids. A larger number of patients is, however, needed to confirm this preliminary study.
Mots-clé
Arteriosclerosis/etiology, Arteriosclerosis/ultrasonography, Carotid Artery Diseases/etiology, Carotid Artery Diseases/ultrasonography, Carotid Artery, Common/ultrasonography, Case-Control Studies, Female, Humans, Male, Middle Aged, Risk Factors, Statistics, Nonparametric, Xanthomatosis/complications
Pubmed
Web of science
Création de la notice
29/01/2008 18:23
Dernière modification de la notice
20/08/2019 17:17
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