CENPV Is a CYLD-Interacting Molecule Regulating Ciliary Acetylated α-Tubulin.

Détails

ID Serval
serval:BIB_EF5AC56294E8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
CENPV Is a CYLD-Interacting Molecule Regulating Ciliary Acetylated α-Tubulin.
Périodique
The Journal of investigative dermatology
Auteur⸱e⸱s
Chiticariu E., Regamey A., Huber M., Hohl D.
ISSN
1523-1747 (Electronic)
ISSN-L
0022-202X
Statut éditorial
Publié
Date de publication
01/2020
Peer-reviewed
Oui
Volume
140
Numéro
1
Pages
66-74.e4
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
CYLD is a deubiquitylase with tumor suppressor functions, first identified in patients with familial cylindromatosis. Despite many molecular mechanisms in which a function of CYLD was reported, affected patients only develop skin appendage tumors, and their precise pathogenesis remains enigmatic. To elucidate how CYLD contributes to tumor formation, we aimed to identify molecular partners in keratinocytes. By using yeast two-hybrid, coprecipitation, and proximity ligation experiments, we identified CENPV as a CYLD-interacting partner. CENPV, a constituent of mitotic chromosomes associating with cytoplasmic microtubules, interacts with CYLD through the region between the third cytoskeleton-associated protein-glycine domain and the active site. CENPV is deubiquitylated by CYLD and localizes in interphase to primary cilia where it increases the ciliary levels of acetylated α-tubulin. CENPV is overexpressed in basal cell carcinoma. Our results support the notion that centromeric proteins have functions in ciliogenesis.
Mots-clé
Acetylation, Carcinogenesis, Carcinoma, Basal Cell/genetics, Carcinoma, Basal Cell/metabolism, Chromosomal Proteins, Non-Histone/genetics, Chromosomal Proteins, Non-Histone/metabolism, Cilia/metabolism, Cloning, Molecular, Cytoskeleton/metabolism, Deubiquitinating Enzyme CYLD/genetics, Deubiquitinating Enzyme CYLD/metabolism, Gene Expression Regulation, Neoplastic, HEK293 Cells, Humans, Keratinocytes/physiology, Neoplastic Syndromes, Hereditary/genetics, Protein Binding, Protein Processing, Post-Translational, Skin Neoplasms/genetics, Skin Neoplasms/metabolism, Tubulin/metabolism, Ubiquitination
Pubmed
Web of science
Open Access
Oui
Création de la notice
18/07/2019 16:21
Dernière modification de la notice
25/07/2020 5:19
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