Anthracene-tethered ruthenium(II) arene complexes as tools to visualize the cellular localization of putative organometallic anticancer compounds.

Détails

ID Serval
serval:BIB_EF5882B3981C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Anthracene-tethered ruthenium(II) arene complexes as tools to visualize the cellular localization of putative organometallic anticancer compounds.
Périodique
Inorganic Chemistry
Auteur(s)
Nazarov A.A., Risse J., Ang W.H., Schmitt F., Zava O., Ruggi A., Groessl M., Scopelitti R., Juillerat-Jeanneret L., Hartinger C.G., Dyson P.J.
ISSN
1520-510X (Electronic)
ISSN-L
0020-1669
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
51
Numéro
6
Pages
3633-3639
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Anthracene derivatives of ruthenium(II) arene compounds with 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane (pta) or a sugar phosphite ligand, viz., 3,5,6-bicyclophosphite-1,2-O-isopropylidene-α-d-glucofuranoside, were prepared in order to evaluate their anticancer properties compared to the parent compounds and to use them as models for intracellular visualization by fluorescence microscopy. Similar IC(50) values were obtained in cell proliferation assays, and similar levels of uptake and accumulation were also established. The X-ray structure of [{Ru(η(6)-C(6)H(5)CH(2)NHCO-anthracene)Cl(2)(pta)] is also reported.
Pubmed
Web of science
Création de la notice
20/03/2012 10:40
Dernière modification de la notice
20/08/2019 17:17
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