Morphology of tyrosine hydroxylase-immunoreactive neurons in the human cerebral cortex
Détails
ID Serval
serval:BIB_EF4ED48DE995
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Morphology of tyrosine hydroxylase-immunoreactive neurons in the human cerebral cortex
Périodique
Experimental Brain Research
ISSN
0014-4819 (Print)
Statut éditorial
Publié
Date de publication
1989
Volume
76
Numéro
1
Pages
12-20
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, Non-U.S. Gov't
Résumé
In freshly fixed biopsies of human cerebral cortex obtained at surgery, immunocytochemical staining with antibodies against tyrosine hydroxylase (the rate limiting biosynthetic enzyme for catecholamines) revealed, in addition to a dense axonal plexus, a population of immunoreactive cell bodies. The neuronal nature of these cells was ascertained by: i) the presence of a rich rough endoplasmic reticulum in the cell body and of synapses on the cell body and dendrites, and ii) the demonstration of the lack of reactivity with the astroglial marker, glial fibrillary acidic protein, in the tyrosine hydroxylase-immunoreactive cells. The tyrosine hydroxylase-immunoreactive neurons were found in all areas of cortex sampled, and were located almost exclusively in the infragranular layers. Most tyrosine hydroxylase-immunoreactive cells were bipolar and were vertically oriented, but a few had a multipolar or horizontal dendritic arbor. The dendrites of these cells were varicose and aspiny, and the axons were very thin. Tyrosine hydroxylase-immunoreactive neurons were reported to be present transiently in the developing mammalian cerebral cortex and only recently in cerebral cortex of mature mammalian brains. Internuncial neurons in the human cerebral cortex containing a catecholamine synthesizing enzyme would be significant, in particular considering that catecholamines are likely to be involved in some major mental disorders.
Mots-clé
Adolescent
Adult
Aged
Cerebral Cortex/*enzymology/ultrastructure
Child
Dopamine/metabolism
Female
Humans
Immunohistochemistry
Male
Microscopy, Electron
Middle Aged
Tyrosine 3-Monooxygenase/*metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 15:22
Dernière modification de la notice
20/08/2019 17:17