Spontaneous viral clearance, viral load, and genotype distribution of hepatitis C virus (HCV) in HIV-infected patients with anti-HCV antibodies in Europe.

Détails

ID Serval
serval:BIB_EEFCBF3D79AF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Spontaneous viral clearance, viral load, and genotype distribution of hepatitis C virus (HCV) in HIV-infected patients with anti-HCV antibodies in Europe.
Périodique
Journal of Infectious Diseases
Auteur⸱e⸱s
Soriano V., Mocroft A., Rockstroh J., Ledergerber B., Knysz B., Chaplinskas S., Peters L., Karlsson A., Katlama C., Toro C., Kupfer B., Vogel M., Lundgren J.
Collaborateur⸱rice⸱s
EuroSIDA Study Group
Contributeur⸱rice⸱s
Losso M., Duran A., Vetter N., Karpov I., Vassilenko A., Clumeck N., De Wit S., Poll B., Colebunders R., Kostov K., Begovac J., Ristola M., Machala L., Rozsypal H., Sedlacek D., Nielsen J., Lundgren J., Benfield T., Kirk O., Gerstoft J., Katzenstein T., Hansen AB., Skinhøj P., Pedersen C., Oestergaard L., Zilmer K., Smidt J., Katlama C., Viard JP., Girard PM., Livrozet JM., Vanhems P., Pradier C., Dabis F., Rockstroh J., Schmidt R., van Lunzen J., Degen O., Stellbrink HJ., Staszewski S., Bogner J., Fätkenheuer G., Kosmidis J., Gargalianos P., Xylomenos G., Perdios J., Panos G., Filandras A., Karabatsaki E., Sambattakou H., Banhegyi D., Mulcahy F., Yust I., Turner D., Burke M., Pollack S., Hassoun G., Maayan S., Chiesi A., Esposito R., Mazeu I., Mussini C., Arici C., Pristera R., Mazzotta F., Gabbuti A., Vullo V., Lichtner M., Chirianni A., Montesarchio E., Gargiulo M., Antonucci G., Iacomi F., Narciso P., Vlassi C., Zaccarelli M., Lazzarin A., Finazzi R., Galli M., Ridolfo A., Sacco OL., d'Arminio Monforte A., Rozentale B., Aldins P., Chaplinskas S., Hemmer R., Staub T., Reiss P., Bruun J., Maeland A., Ormaasen V., Knysz B., Gasiorowski J., Horban A., Prokopowicz D., Wiercinska-Drapalo A., Boron-Kaczmarska A., Pynka M., Beniowski M., Mularska E., Trocha H., Antunes F., Valadas E., Mansinho K., Maltez F., Duiculescu D., Babes V., Rakhmanova A., Vinogradova E., Buzunova S., Jevtovic D., Mokrás M., Staneková D., González-Lahoz J., Soriano V., Martin-Carbonero L., Labarga P., Clotet B., Jou A., Conejero J., Tural C., Gatell JM., Miró JM., Domingo P., Gutierrez M., Mateo G., Sambeat MA., Karlsson A., Persson PO., Flamholc L., Ledergerber B., Weber R., Francioli P., Cavassini M., Hirschel B., Boffi E., Furrer H., Battegay M., Elzi L., Kravchenko E., Chentsova N., Barton S., Johnson AM., Mercey D., Phillips A., Johnson MA., Mocroft A., Murphy M., Weber J., Scullard G., Fisher M., Brettle R., Clotet B., Antunes F., Clotet B., Duiculescu D., Gatell J., Gazzard B., Horban A., Karlsson A., Katlama C., Ledergerber B., D'Arminio Montforte A., Phillips A., Rakhmanova A., Reiss P., Rockstroh J., Lundgren J., Kirk O., Mocroft A., Friis- Møller N., Cozzi-Lepri A., Bannister W., Ellefson M., Borch A., Podlevkareva D., Holkmann Olsen C., Kjaer J., Peters L., Reekie J.
ISSN
0022-1899 (Print)
ISSN-L
0022-1899
Statut éditorial
Publié
Date de publication
11/2008
Peer-reviewed
Oui
Volume
198
Numéro
9
Pages
1337-1344
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
BACKGROUND: Variables influencing serum hepatitis C virus (HCV) RNA levels and genotype distribution in individuals with human immunodeficiency virus (HIV) infection are not well known, nor are factors determining spontaneous clearance after exposure to HCV in this population.
METHODS: All HCV antibody (Ab)-positive patients with HIV infection in the EuroSIDA cohort who had stored samples were tested for serum HCV RNA, and HCV genotyping was done for subjects with viremia. Logistic regression was used to identify variables associated with spontaneous HCV clearance and HCV genotype 1.
RESULTS: Of 1940 HCV Ab-positive patients, 1496 (77%) were serum HCV RNA positive. Injection drug users (IDUs) were less likely to have spontaneously cleared HCV than were homosexual men (20% vs. 39%; adjusted odds ratio [aOR], 0.36 [95% confidence interval {CI}, 0.24-0.53]), whereas patients positive for hepatitis B surface antigen (HBsAg) were more likely to have spontaneously cleared HCV than were those negative for HBsAg (43% vs. 21%; aOR, 2.91 [95% CI, 1.94-4.38]). Of patients with HCV viremia, 786 (53%) carried HCV genotype 1, and 53 (4%), 440 (29%), and 217 (15%) carried HCV genotype 2, 3, and 4, respectively. A greater HCV RNA level was associated with a greater chance of being infected with HCV genotype 1 (aOR, 1.60 per 1 log higher [95% CI, 1.36-1.88]).
CONCLUSIONS: More than three-quarters of the HIV- and HCV Ab-positive patients in EuroSIDA showed active HCV replication. Viremia was more frequent in IDUs and, conversely, was less common in HBsAg-positive patients. Of the patients with HCV viremia analyzed, 53% were found to carry HCV genotype 1, and this genotype was associated with greater serum HCV RNA levels.
Mots-clé
Adult, Antibodies, Viral/blood, Argentina/epidemiology, Europe/epidemiology, Female, HIV Infections/complications, HIV Infections/epidemiology, Hepacivirus/genetics, Hepatitis C/complications, Hepatitis C/epidemiology, Host-Pathogen Interactions, Humans, Incidence, Israel/epidemiology, Male, Prevalence, Viral Load
Pubmed
Web of science
Open Access
Oui
Création de la notice
06/03/2009 8:28
Dernière modification de la notice
20/08/2019 16:16
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