A polymorphism in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro.
Détails
ID Serval
serval:BIB_EEF89794343D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A polymorphism in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro.
Périodique
Aids
ISSN
1473-5571 (Electronic)
ISSN-L
0269-9370
Statut éditorial
Publié
Date de publication
2010
Volume
24
Numéro
1
Pages
155-157
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., ExtramuralPublication Status: ppublish
Résumé
A single-nucleotide polymorphism (rs2395029) in the HCP5 gene associated with HLA-B*5701 is correlated with lower HIV-1 viral set point. The two allelic forms of coding region were ectopically expressed in TZM-bl cells for an effect on HIV-1 replication. No significant HIV-1 restriction was observed in the cells with infectivity assays throughout HIV-1 life cycle, suggesting that the association of HCP5 variant with viral control is likely due to HLA-B*5701-related effect or other functional variants in the haplotype or both.
Mots-clé
HIV Infections/genetics, HIV Infections/virology, HIV-1/genetics, HLA-B Antigens/genetics, Humans, Major Histocompatibility Complex/genetics, Polymorphism, Single Nucleotide, Viral Load
Pubmed
Web of science
Création de la notice
01/03/2012 16:14
Dernière modification de la notice
20/08/2019 17:16
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