The functional role of beta subunits in oligomeric P-type ATPases

Détails

ID Serval
serval:BIB_EEA65214EAC6
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
The functional role of beta subunits in oligomeric P-type ATPases
Périodique
Journal of Bioenergetics and Biomembranes
Auteur⸱e⸱s
Geering  K.
ISSN
0145-479X (Print)
Statut éditorial
Publié
Date de publication
10/2001
Volume
33
Numéro
5
Pages
425-38
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Oct
Résumé
Na,K-ATPase and gastric and nongastric H,K-ATPases are the only P-type ATPases of higher organisms that are oligomeric and are associated with a beta subunit, which is obligatory for expression and function of enzymes. Topogenesis studies suggest that beta subunits have a fundamental and unique role in K+-transporting P-type ATPases in that they facilitate the correct membrane integration and packing of the catalytic a subunit of these P-type ATPases, which is necessary for their resistance to cellular degradation, their acquisition of functional properties, and their routing to the cell surface. In addition to this chaperone function, beta subunits also participate in the determination of intrinsic transport properties of Na,K- and H,K-ATPases. Increasing experimental evidence suggests that beta assembly is a highly ordered, beta isoform-specific process, which is mediated by multiple interaction sites that contribute in a coordinate, multistep process to the structural and functional maturation of Na,K- and H,K-ATPases.
Mots-clé
Adenosine Triphosphatases/chemistry/genetics/metabolism Amino Acid Sequence H(+)-K(+)-Exchanging ATPase/genetics/*physiology Molecular Chaperones/physiology Na(+)-K(+)-Exchanging ATPase/genetics/*physiology Protein Isoforms/metabolism *Protein Subunits
Pubmed
Web of science
Création de la notice
24/01/2008 12:28
Dernière modification de la notice
20/08/2019 16:16
Données d'usage