Metabolic activation pattern of distinct hippocampal subregions during spatial learning and memory retrieval.

Détails

ID Serval
serval:BIB_EE95170D1BB4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Metabolic activation pattern of distinct hippocampal subregions during spatial learning and memory retrieval.
Périodique
Journal of Cerebral Blood Flow and Metabolism
Auteur(s)
Ros J., Pellerin L., Magara F., Dauguet J., Schenk F., Magistretti P.J.
ISSN
0271-678X
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
26
Numéro
4
Pages
468-477
Langue
anglais
Résumé
Activation dynamics of hippocampal subregions during spatial learning and their interplay with neocortical regions is an important dimension in the understanding of hippocampal function. Using the (14C)-2-deoxyglucose autoradiographic method, we have characterized the metabolic changes occurring in hippocampal subregions in mice while learning an eight-arm radial maze task. Autoradiogram densitometry revealed a heterogeneous and evolving pattern of enhanced metabolic activity throughout the hippocampus during the training period and on recall. In the early stages of training, activity was enhanced in the CA1 area from the intermediate portion to the posterior end as well as in the CA3 area within the intermediate portion of the hippocampus. At later stages, CA1 and CA3 activations spread over the entire longitudinal axis, while dentate gyrus (DG) activation occurred from the anterior to the intermediate zone. Activation of the retrosplenial cortex but not the amygdala was also observed during the learning process. On recall, only DG activation was observed in the same anterior part of the hippocampus. These results suggest the existence of a functional segmentation of the hippocampus, each subregion being dynamically but also differentially recruited along the acquisition, consolidation, and retrieval process in parallel with some neocortical sites.
Mots-clé
Animals, Autoradiography, Dentate Gyrus, Deoxyglucose, Hippocampus, Learning, Male, Maze Learning, Metabolism, Mice, Mice, Inbred C57BL, Neocortex, Retention (Psychology)
Pubmed
Web of science
Création de la notice
05/02/2008 13:39
Dernière modification de la notice
20/08/2019 16:16
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