Gut microbiota analysis reveals a marked shift to bifidobacteria by a starter infant formula containing a synbiotic of bovine milk-derived oligosaccharides and Bifidobacterium animalis subsp. lactis CNCM I-3446.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_EE3F587B3B27
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Gut microbiota analysis reveals a marked shift to bifidobacteria by a starter infant formula containing a synbiotic of bovine milk-derived oligosaccharides and Bifidobacterium animalis subsp. lactis CNCM I-3446.
Périodique
Environmental microbiology
Auteur(s)
Simeoni U., Berger B., Junick J., Blaut M., Pecquet S., Rezzonico E., Grathwohl D., Sprenger N., Brüssow H., Szajewska H., Bartoli J.M., Brevaut-Malaty V., Borszewska-Kornacka M., Feleszko W., François P., Gire C., Leclaire M., Maurin J.M., Schmidt S., Skórka A., Squizzaro C., Verdot J.J.
Collaborateur(s)
Study Team
ISSN
1462-2920 (Electronic)
ISSN-L
1462-2912
Statut éditorial
Publié
Date de publication
07/2016
Peer-reviewed
Oui
Volume
18
Numéro
7
Pages
2185-2195
Langue
anglais
Notes
Publication types: Journal Article ; Randomized Controlled Trial
Publication Status: ppublish
Résumé
Non-digestible milk oligosaccharides were proposed as receptor decoys for pathogens and as nutrients for beneficial gut commensals like bifidobacteria. Bovine milk contains oligosaccharides, some of which are structurally identical or similar to those found in human milk. In a controlled, randomized double-blinded clinical trial we tested the effect of feeding a formula supplemented with a mixture of bovine milk-derived oligosaccharides (BMOS) generated from whey permeate, containing galacto-oligosaccharides and 3'- and 6'-sialyllactose, and the probiotic Bifidobacterium animalis subsp. lactis (B. lactis) strain CNCM I-3446. Breastfed infants served as reference group. Compared with a non-supplemented control formula, the test formula showed a similar tolerability and supported a similar growth in healthy newborns followed for 12 weeks. The control, but not the test group, differed from the breast-fed reference group by a higher faecal pH and a significantly higher diversity of the faecal microbiota. In the test group the probiotic B. lactis increased by 100-fold in the stool and was detected in all supplemented infants. BMOS stimulated a marked shift to a bifidobacterium-dominated faecal microbiota via increases in endogenous bifidobacteria (B. longum, B. breve, B. bifidum, B. pseudocatenulatum).

Mots-clé
Animals, Bacteria/classification, Bacteria/genetics, Bacteria/growth & development, Bacteria/isolation & purification, Bifidobacterium animalis/genetics, Bifidobacterium animalis/growth & development, Bifidobacterium animalis/isolation & purification, Bifidobacterium animalis/metabolism, Cattle, Feces/microbiology, Female, Food Additives/analysis, Food Additives/metabolism, Gastrointestinal Microbiome, Humans, Infant, Infant Formula/analysis, Infant, Newborn, Male, Milk/chemistry, Milk/metabolism, Oligosaccharides/analysis, Oligosaccharides/metabolism, Synbiotics/analysis
Pubmed
Web of science
Open Access
Oui
Création de la notice
02/09/2016 16:11
Dernière modification de la notice
20/08/2019 17:15
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