Calcium homeostasis in aging neurons.
Détails
ID Serval
serval:BIB_EE08C99523A4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Calcium homeostasis in aging neurons.
Périodique
Frontiers in genetics
ISSN
1664-8021 (Electronic)
ISSN-L
1664-8021
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
3
Pages
200
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Résumé
The nervous system becomes increasingly vulnerable to insults and prone to dysfunction during aging. Age-related decline of neuronal function is manifested by the late onset of many neurodegenerative disorders, as well as by reduced signaling and processing capacity of individual neuron populations. Recent findings indicate that impairment of Ca(2+) homeostasis underlies the increased susceptibility of neurons to damage, associated with the aging process. However, the impact of aging on Ca(2+) homeostasis in neurons remains largely unknown. Here, we survey the molecular mechanisms that mediate neuronal Ca(2+) homeostasis and discuss the impact of aging on their efficacy. To address the question of how aging impinges on Ca(2+) homeostasis, we consider potential nodes through which mechanisms regulating Ca(2+) levels interface with molecular pathways known to influence the process of aging and senescent decline. Delineation of this crosstalk would facilitate the development of interventions aiming to fortify neurons against age-associated functional deterioration and death by augmenting Ca(2+) homeostasis.
Mots-clé
Golgi, endoplasmic reticulum, ion channel, long-term potentiation, mitochondria, neurodegeneration, neurotransmitter, synaptic plasticity
Pubmed
Open Access
Oui
Création de la notice
04/06/2024 11:02
Dernière modification de la notice
05/06/2024 9:08