Blood microvesicles: from proteomics to physiology

Détails

Ressource 1Demande d'une copie Sous embargo indéterminé.
Etat: Public
Version: Final published version
ID Serval
serval:BIB_ED95246059FD
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Blood microvesicles: from proteomics to physiology
Périodique
Translational Proteomics
Auteur(s)
Tissot J.D., Canellini G., Rubin O., Angelillo-Scherrer A., Delobel J., Prudent M., Lion N.
ISSN
2212-9626
ISSN-L
2212-9634 (Print)
Statut éditorial
Publié
Date de publication
2013
Volume
1
Numéro
1
Pages
38-52
Langue
anglais
Résumé
Phospholipid vesicles of less than 1 μm are present in blood in physiological state and their concentration may vary under pathological conditions. Various names such as exosomes (EXS) and microparticles (MPS) have been used to designate these extracellular vesicles (EVS). Although EXs and MPS possibly arise from separate mechanisms, they share numerous similarities representing a challenge for their purification and characterization. These vesicles generally originate from various types of cells such as red blood cells, platelets, leukocytes or endothelial cells but also from tumor cells. They participate in numerous biological processes including hemostasis. It is therefore of major scientific interest to characterize the protein content of these different types of EVS and that of their membranes in order to elucidate the essential functions of these dynamic vesicular compartments. Proteomics has been shown to be a particularly adequate tool in this study field. This review attempts to link proteomic data with physiological roles and functions of blood EVS.
Open Access
Oui
Création de la notice
11/11/2014 11:30
Dernière modification de la notice
20/08/2019 16:15
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