Influence of infusion line compliance on drug delivery rate during acute line loop formation.

Détails

ID Serval
serval:BIB_ED73E13F96A2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Influence of infusion line compliance on drug delivery rate during acute line loop formation.
Périodique
Intensive care medicine
Auteur(s)
Weiss M., Bänziger O., Neff T., Fanconi S.
ISSN
0342-4642
Statut éditorial
Publié
Date de publication
2000
Peer-reviewed
Oui
Volume
26
Numéro
6
Pages
776-9
Langue
anglais
Notes
Publication types: Comparative Study ; In Vitro ; Journal Article - Publication Status: ppublish
Résumé
OBJECTIVE: To determine whether infusion line compliance contributes to irregular drug delivery during vertical displacement of syringe pumps. DESIGN: Five different commercially available infusion lines were studied at infusion rates of 0.5, 1.0, and 1.5 ml/h. Zero drug delivery time was measured after acute line loop formation (70 cm) using an electronic balance. Compliance of each infusion line was calculated using a pressure transducer and measurement of the occlusion release bolus at 300 mmHg occlusion pressure. Finally, the influence of infusion line compliance on drug delivery during acute lowering of the syringe pump was studied using low- and high-compliance infusion lines. RESULTS: Acute line loop formation resulted in zero drug delivery time from 5.1 +/- 1.5 to 44.0 +/- 6.8 s at flow rates of 0.5 ml/h. Increased flow rates significantly reduced loop-induced flow variability. A close correlation was found between zero drug delivery time and calculated infusion line compliance at 0.5 ml/h (linear regression R2 = 0.79). Lowering of the syringe pump 50 cm prolonged zero drug delivery time from 295.8 +/- 20.7 s with the low-compliance tube to 463.3 +/- 24.0 s with the high-compliance infusion line. CONCLUSIONS: Infusion line compliance contributes to irregular drug delivery associated with vertical displacement of syringe pumps. Siphoning of the infusion line during patient care should be avoided, and flow rates of 1 ml/h or higher are recommended. Low-compliance infusion lines are indicated whenever highly short-acting vasoactive drugs at low delivery rates are administered.
Mots-clé
Child, Equipment Design, Hemodynamics, Humans, Infant, Newborn, Infusion Pumps, Infusions, Intravenous, Intensive Care Units, Pediatric, Time Factors
Pubmed
Web of science
Création de la notice
25/01/2008 10:07
Dernière modification de la notice
20/08/2019 16:15
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