Atypical hematological manifestation of celiac disease: A case report of aplastic anemia in a 2-year-old child and review of the literature.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY-NC-ND 4.0
ID Serval
serval:BIB_ED565C60A734
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Atypical hematological manifestation of celiac disease: A case report of aplastic anemia in a 2-year-old child and review of the literature.
Périodique
Pediatric investigation
Auteur⸱e⸱s
von Graffenried T., Rizzi M., Russo M., Nydegger A., Kayemba-Kay's S.
ISSN
2574-2272 (Electronic)
ISSN-L
2574-2272
Statut éditorial
Publié
Date de publication
06/2021
Peer-reviewed
Oui
Volume
5
Numéro
2
Pages
159-162
Langue
anglais
Notes
Publication types: Case Reports
Publication Status: epublish
Résumé
Celiac disease typically presents with symptoms of malabsorption, but extraintestinal manifestations are increasingly reported. Aplastic anemia as the mode of celiac disease presentation is extremely rare in children.
We report a 2-year-old boy who presented with loose stools, loss of appetite, and bicytopenia with severe aregenerative normocytic anemia. Investigations, including bone marrow aspirate and biopsy, revealed aplastic anemia. Screening for malabsorption showed increased plasma concentrations of anti-transglutaminase and anti-gliadin antibodies. A duodenal biopsy confirmed the histologic features of celiac disease. The child received a packed red cell transfusion and was started on a gluten-free diet, with a very good prognosis and normalization of both his blood and histological parameters. To the best of our knowledge, our report is the sixth pediatric case in the literature.
Screening for celiac disease should be performed in children with unexplained hematological abnormalities such as aplastic anemia with or without gastrointestinal symptoms.
Mots-clé
Aplastic anemia, Celiac disease, Child, Gluten‐free diet
Pubmed
Open Access
Oui
Création de la notice
06/07/2021 10:36
Dernière modification de la notice
12/01/2022 7:14
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