Corneal Stromal Demarcation Line Depth Following Standard and a Modified High Intensity Corneal Cross-linking Protocol.

Détails

ID Serval
serval:BIB_ED3C5D1A66A1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Corneal Stromal Demarcation Line Depth Following Standard and a Modified High Intensity Corneal Cross-linking Protocol.
Périodique
Journal of refractive surgery
Auteur⸱e⸱s
Kymionis G.D., Tsoulnaras K.I., Liakopoulos D.A., Skatharoudi C.A., Grentzelos M.A., Tsakalis N.G.
ISSN
1081-597X (Print)
ISSN-L
1081-597X
Statut éditorial
Publié
Date de publication
04/2016
Peer-reviewed
Oui
Volume
32
Numéro
4
Pages
218-222
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article
Publication Status: ppublish
Résumé
To compare the corneal stromal demarcation line depth using anterior segment optical coherence tomography (AS-OCT) after corneal cross-linking (CXL) using two different treatment protocols: the standard Dresden protocol (30 minutes with 3 mW/cm(2)) and a modified high intensity protocol (7 minutes with 18 mW/cm(2)), corresponding to a total surface dose of 5.4 and 7.5 J/cm(2), respectively.
This prospective, comparative, interventional case series included 29 keratoconic patients (32 eyes). All patients underwent CXL using the same high intensity ultraviolet-A (UV-A) irradiation device (CCL-365; Peschke Meditrade GmbH, Huenenberg, Switzerland). Sixteen eyes were treated for 30 minutes with 3 mW/cm(2) according to the standard Dresden protocol, whereas 16 eyes were treated with a novel modified high intensity CXL protocol for 7 minutes with 18 mW/cm(2) of UV-A irradiation intensity. One month postoperatively, corneal stromal demarcation line depth was measured by two independent observers using AS-OCT.
There was no significant difference in corneal stromal demarcation line depth between observer measurements for both groups (P = .645, Dresden protocol group; P = .715, high intensity group). Mean corneal stromal demarcation line depth was 341.81 ± 47.02 µm for the Dresden protocol group and 313.37 ± 48.85 µm for the high intensity protocol group. There was no statistically significant difference (P = .104) in the corneal stromal demarcation line depth between the two groups. Mean endothelial cell density did not change significantly in either group (P = .090, Dresden protocol group; P = .103, high intensity group). No intraoperative or postoperative complications were noted.
Corneal stromal demarcation line depth using UV-A irradiance with 3 mW/cm(2) for 30 minutes and 18 mW/cm(2) for 7 minutes was similar. It seems that the current modified accelerated CXL protocol provided the same treatment depth as the standard Dresden protocol.
Mots-clé
Adult, Anatomic Landmarks, Collagen/metabolism, Corneal Stroma/drug effects, Corneal Stroma/metabolism, Corneal Stroma/pathology, Corneal Topography, Cross-Linking Reagents, Female, Humans, Keratoconus/diagnosis, Keratoconus/drug therapy, Keratoconus/metabolism, Male, Observer Variation, Photochemotherapy/methods, Photosensitizing Agents/therapeutic use, Prospective Studies, Riboflavin/therapeutic use, Tomography, Optical Coherence, Ultraviolet Rays, Young Adult
Pubmed
Web of science
Création de la notice
30/09/2019 15:56
Dernière modification de la notice
06/10/2019 5:26
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