Cell biology in neuroscience: Death of developing neurons: new insights and implications for connectivity.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY-NC-SA 4.0
ID Serval
serval:BIB_ED10E73E7FAC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Cell biology in neuroscience: Death of developing neurons: new insights and implications for connectivity.
Périodique
The Journal of cell biology
Auteur⸱e⸱s
Dekkers M.P., Nikoletopoulou V., Barde Y.A.
ISSN
1540-8140 (Electronic)
ISSN-L
0021-9525
Statut éditorial
Publié
Date de publication
11/11/2013
Peer-reviewed
Oui
Volume
203
Numéro
3
Pages
385-393
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
The concept that target tissues determine the survival of neurons has inspired much of the thinking on neuronal development in vertebrates, not least because it is supported by decades of research on nerve growth factor (NGF) in the peripheral nervous system (PNS). Recent discoveries now help to understand why only some developing neurons selectively depend on NGF. They also indicate that the survival of most neurons in the central nervous system (CNS) is not simply regulated by single growth factors like in the PNS. Additionally, components of the cell death machinery have begun to be recognized as regulators of selective axonal degeneration and synaptic function, thus playing a critical role in wiring up the nervous system.
Mots-clé
Animals, Apoptosis, Cell Survival, Central Nervous System/embryology, Central Nervous System/metabolism, Humans, Mice, Nerve Growth Factor/metabolism, Neurogenesis/physiology, Neurons/metabolism, Peripheral Nervous System/embryology, Peripheral Nervous System/metabolism, Receptor, trkA/metabolism, Receptor, trkB/metabolism, Receptor, trkC/metabolism, Receptors, Nerve Growth Factor/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
27/01/2021 15:52
Dernière modification de la notice
30/04/2021 6:16
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