Is screening for fetal anomalies reliable in HIV-infected pregnant women? A multicentre study.

Détails

ID Serval
serval:BIB_ED0149B4962D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Is screening for fetal anomalies reliable in HIV-infected pregnant women? A multicentre study.
Périodique
Aids
Auteur⸱e⸱s
Brossard P., Boulvain M., Coll O., Barlow P., Aebi-Popp K., Bischof P., Martinez de Tejada B.
Collaborateur⸱rice⸱s
Swiss HIV Cohort Study, Swiss HIV Mother, Child Cohort Study
Contributeur⸱rice⸱s
Aebi C., Battegay M., Bernasconi E., Böni J., Brazzola P., Bucher HC., Bürgisser P., Calmy A., Cattacin S., Cavassini M., Cheseaux JJ., Drack G., Dubs R., Egger M., Elzi L., Fischer M., Flepp M., Fontana A., Francioli P., Furrer HJ., Fux C., Gayet-Ageron A., Gerber S., Gorgievski M., Grawe C., Günthard H., Gyr T., Hirsch H., Hirschel B., Hösli I., Hüsler M., Kaiser L., Kahlert Ch., Karrer U., Kind C., Klimkait T., Ledergerber B., Martinetti G., Martinez B., Müller N., Nadal D., Opravil M., Paccaud F., Pantaleo G., Rauch A., Regenass S., Rickenbach M., Rudin C., Schmid P., Schultze D., Schüpbach J., Speck R., Taffé P., Telenti A., Trkola A., Vernazza P., Weber R., Wunder D., Wyler CA., Yerly S.
ISSN
1473-5571 (Electronic)
ISSN-L
0269-9370
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
22
Numéro
15
Pages
2013-2017
Langue
anglais
Notes
Publication types: Evaluation Studies ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
OBJECTIVE: To assess the impact of HIV infection on the reliability of the first-trimester screening for Down syndrome, using free beta-human chorionic gonadotrophin, pregnancy-associated plasma protein-A and fetal nuchal translucency, and of the second-trimester screening for neural tube defects, using alpha-fetoprotein.
PATIENTS AND METHODS: Multicentre study comparing the multiples of the median of markers for Down syndrome and neural tube defect screening among 214 HIV-infected pregnant women and 856 HIV-negative controls undergoing a first-trimester Down syndrome screening test, and 209 HIV-positive women and 836 HIV-negative controls with a risk evaluation for neural tube defect. The influence of treatment, chronic hepatitis and HIV disease characteristics were also evaluated.
RESULTS: Multiples of the median medians for pregnancy-associated plasma protein-A and beta-human chorionic gonadotrophin were lower in HIV-positive women than controls (0.88 vs. 1.05 and 0.84 vs. 1.09, respectively; P < 0.005), but these differences had no impact on risk estimation; no differences were observed for the other markers. No association was found between HIV disease characteristics, antiretroviral treatment use at the time of screening or chronic hepatitis and marker levels.
CONCLUSION: Screening for Down syndrome during the first trimester and for neural tube defect during the second trimester is accurate for HIV-infected women and should be offered, similar to HIV-negative women.
Mots-clé
Adult, Biological Markers/blood, Chorionic Gonadotropin, beta Subunit, Human/blood, Down Syndrome/diagnosis, Female, Fetal Diseases/diagnosis, HIV Infections/blood, Humans, Mass Screening/methods, Neural Tube Defects/diagnosis, Nuchal Translucency Measurement, Pregnancy, Pregnancy Complications, Infectious/blood, Pregnancy-Associated Plasma Protein-A/analysis, Prenatal Diagnosis/methods, alpha-Fetoproteins/analysis
Pubmed
Web of science
Création de la notice
06/03/2009 8:18
Dernière modification de la notice
20/08/2019 16:14
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