The role of transepithelial transport by M cells in microbial invasion and host defense

Détails

ID Serval
serval:BIB_EC97F26959C7
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
The role of transepithelial transport by M cells in microbial invasion and host defense
Périodique
Journal of Cell Science. Supplement
Auteur⸱e⸱s
Neutra  M. R., Kraehenbuhl  J. P.
ISSN
0269-3518 (Print)
Statut éditorial
Publié
Date de publication
1993
Volume
17
Pages
209-15
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review
Résumé
Transepithelial transport of antigens by M cells in the epithelium associated with lymphoid follicles in the intestine delivers immunogens directly to organized mucosal lymphoid tissues, the inductive sites for mucosal immune responses. We have exploited M cell transport to generate and characterize specific monoclonal IgA antibodies that can prevent interaction of pathogens with epithelial surfaces. The relative protective capacities of specific monoclonal IgA antibodies have been tested in vivo by generation of hybridoma tumors that result in secretion of monoclonal IgA into the intestine. Using this method, we have established that secretion of IgA antibodies recognizing a single surface epitope on enteric pathogens can provide protection against colonization or invasion of the intestinal mucosa.
Mots-clé
Animals Antibodies, Monoclonal/metabolism Antigens/metabolism Bacteria/immunology Biological Transport, Active Epithelium/immunology/microbiology Humans Immunoglobulin A, Secretory/*metabolism Intestinal Mucosa/cytology/*immunology/microbiology Lymphoid Tissue/cytology/immunology/microbiology Salmonella/immunology Viruses/immunology
Pubmed
Web of science
Création de la notice
25/01/2008 15:05
Dernière modification de la notice
20/08/2019 16:14
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