Treatment of relapsing acute lymphoblastic leukemia in childhood. III. Experiences with 54 first bone marrow, nine isolated testicular, and eight isolated central nervous system relapses observed 1985-1989

Détails

ID Serval
serval:BIB_EC6E4433BAF4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Treatment of relapsing acute lymphoblastic leukemia in childhood. III. Experiences with 54 first bone marrow, nine isolated testicular, and eight isolated central nervous system relapses observed 1985-1989
Périodique
Medical and Pediatric Oncology
Auteur(s)
von der Weid  N., Wagner  B., Angst  R., Arnet  B., Baumgartner  C., Beck  D., Bleher  A., Caflisch  U., Delaleu  B., Feldges  A., Frey  E., Glanzmann  I., Hirt  A., Imbach  P., Kratel  S., Kuchler  H., Leibundgut  K., Meister  A., Morin  A.M., Nobile  L., Pluss  H.J., Luthy  A.R., Signer  E., Stettler  E., Wyss  M., Wagner  H.P.
ISSN
0098-1532 (Print)
Statut éditorial
Publié
Date de publication
1994
Volume
22
Numéro
6
Pages
361-9
Notes
Journal Article
Résumé
Of 54 children with acute lymphoblastic leukemia (ALL) and first hematological recurrence observed between 1985 and 1989, 31 relapsed while still on treatment and 23 after cessation of therapy. Of the former, only one survived. Of the latter, 11 children survived after a minimum follow-up of 25 months. During the same period, a first isolated testicular relapse was observed in nine boys, of whom six survived, and an isolated CNS relapse in eight patients, of whom three survived. As a rule, survivors of a bone marrow or testicular relapse were doing well while those surviving a CNS relapse had considerable neuropsychological sequelae. These results, compared with those of two preceding studies, suggest that with intensification of front-line treatments, it becomes more difficult to rescue children who relapse, particularly those with a bone marrow relapse while on therapy.
Mots-clé
Adolescent Bone Marrow Diseases/mortality/*therapy Central Nervous System Neoplasms/mortality/*therapy Child Child, Preschool Combined Modality Therapy Female Follow-Up Studies Humans Leukemia, Lymphocytic, Acute, L1/mortality/*therapy Male Quality of Life Recurrence Retrospective Studies Survival Rate Testicular Neoplasms/mortality/*therapy Treatment Outcome
Pubmed
Web of science
Création de la notice
25/01/2008 11:35
Dernière modification de la notice
20/08/2019 17:14
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