Population genetic differentiation of height and body mass index across Europe.

Détails

ID Serval
serval:BIB_EC18B971C062
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Population genetic differentiation of height and body mass index across Europe.
Périodique
Nature Genetics
Auteur⸱e⸱s
Robinson M.R., Hemani G., Medina-Gomez C., Mezzavilla M., Esko T., Shakhbazov K., Powell J.E., Vinkhuyzen A., Berndt S.I., Gustafsson S., Justice A.E., Kahali B., Locke A.E., Pers T.H., Vedantam S., Wood A.R., van Rheenen W., Andreassen O.A., Gasparini P., Metspalu A., Berg L.H., Veldink J.H., Rivadeneira F., Werge T.M., Abecasis G.R., Boomsma D.I., Chasman D.I., de Geus E.J., Frayling T.M., Hirschhorn J.N., Hottenga J.J., Ingelsson E., Loos R.J., Magnusson P.K., Martin N.G., Montgomery G.W., North K.E., Pedersen N.L., Spector T.D., Speliotes E.K., Goddard M.E., Yang J., Visscher P.M.
ISSN
1546-1718 (Electronic)
ISSN-L
1061-4036
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
47
Numéro
11
Pages
1357-1362
Langue
anglais
Résumé
Across-nation differences in the mean values for complex traits are common, but the reasons for these differences are unknown. Here we find that many independent loci contribute to population genetic differences in height and body mass index (BMI) in 9,416 individuals across 14 European countries. Using discovery data on over 250,000 individuals and unbiased effect size estimates from 17,500 sibling pairs, we estimate that 24% (95% credible interval (CI) = 9%, 41%) and 8% (95% CI = 4%, 16%) of the captured additive genetic variance for height and BMI, respectively, reflect population genetic differences. Population genetic divergence differed significantly from that in a null model (height, P < 3.94 × 10(-8); BMI, P < 5.95 × 10(-4)), and we find an among-population genetic correlation for tall and slender individuals (r = -0.80, 95% CI = -0.95, -0.60), consistent with correlated selection for both phenotypes. Observed differences in height among populations reflected the predicted genetic means (r = 0.51; P < 0.001), but environmental differences across Europe masked genetic differentiation for BMI (P < 0.58).

Mots-clé
Algorithms, Body Height/genetics, Body Mass Index, Europe, Gene Expression Profiling/methods, Gene Expression Profiling/statistics & numerical data, Gene-Environment Interaction, Genetic Variation, Genetics, Population/methods, Genetics, Population/statistics & numerical data, Genome-Wide Association Study/methods, Genome-Wide Association Study/statistics & numerical data, Genotype, Geography, Humans, Models, Genetic, Phenotype, Polymorphism, Single Nucleotide, Principal Component Analysis
Pubmed
Web of science
Création de la notice
06/12/2017 13:42
Dernière modification de la notice
20/08/2019 17:14
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