Monoaminergic afferents to cortex modulate structural plasticity in the barrelfield of the mouse

Détails

ID Serval
serval:BIB_EC1181A3ABB6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Monoaminergic afferents to cortex modulate structural plasticity in the barrelfield of the mouse
Périodique
Brain Research. Developmental Brain Research
Auteur⸱e⸱s
Osterheld-Haas  M. C., Van der Loos  H., Hornung  J. P.
ISSN
0165-3806 (Print)
Statut éditorial
Publié
Date de publication
02/1994
Volume
77
Numéro
2
Pages
189-202
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S. --- Old month value: Feb 18
Résumé
Electrolytic lesions of the follicles of a set of mystacial vibrissae, and their innervation, of the mouse placed during the early postnatal period result in a modification in appearance of the corresponding and of adjacent barrels in the somatosensory cortex of the adult animal. These changes can be evoked during the first 6 days of postnatal life--the so-called critical period. The pattern of these modifications varies with the age of the animal at which the lesion was placed. In order to evaluate the contribution of the monoaminergic cortical input to this type of plasticity, the noradrenergic and/or serotonergic afferents to the cerebral cortex of newborn mice were destroyed by systemic administration of various selective neurotoxic drugs (6-hydroxydopamine, 5,7-dihydroxytryptamine, N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine). The animals were then subjected, on postnatal day 3 (P3; P0 = day of birth), to a lesion of the follicles of the large, caudal mystacial vibrissae of row C. Control animals were injected with vehicle solution only but had the same follicles lesioned. Compared with animals with intact monoaminergic afferents, those treated with neurotoxins showed a different changed barrel pattern, i.e. one that corresponded to a pattern normally obtained after a lesion placed at an earlier stage of development, i.e. at P2 or P1. Thus, monoaminergic depletion of the cortex results in a retardation of the maturation of the parietal cortex as defined by its plastic response to peripheral nerve injury.(ABSTRACT TRUNCATED AT 250 WORDS)
Mots-clé
Animals Biogenic Monoamines/*physiology Chromatography, High Pressure Liquid Denervation Mice Mice, Inbred ICR Nerve Fibers/physiology Neuronal Plasticity/*physiology Neurons, Afferent/*physiology Neurotoxins/pharmacology Peripheral Nerves/physiology Somatosensory Cortex/anatomy & histology/*physiology Vibrissae/*innervation
Pubmed
Création de la notice
24/01/2008 14:22
Dernière modification de la notice
20/08/2019 16:14
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