The Quest for Orthologs benchmark service and consensus calls in 2020.

Détails

Ressource 1Télécharger: 32374845_BIB_EBF2C2C4065D.pdf (2900.81 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_EBF2C2C4065D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The Quest for Orthologs benchmark service and consensus calls in 2020.
Périodique
Nucleic acids research
Auteur(s)
Altenhoff A.M., Garrayo-Ventas J., Cosentino S., Emms D., Glover N.M., Hernández-Plaza A., Nevers Y., Sundesha V., Szklarczyk D., Fernández J.M., Codó L., For Orthologs Consortium T.Q., Gelpi J.L., Huerta-Cepas J., Iwasaki W., Kelly S., Lecompte O., Muffato M., Martin M.J., Capella-Gutierrez S., Thomas P.D., Sonnhammer E., Dessimoz C.
ISSN
1362-4962 (Electronic)
ISSN-L
0305-1048
Statut éditorial
Publié
Date de publication
02/07/2020
Peer-reviewed
Oui
Volume
48
Numéro
W1
Pages
W538-W545
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
Publication Status: ppublish
Résumé
The identification of orthologs-genes in different species which descended from the same gene in their last common ancestor-is a prerequisite for many analyses in comparative genomics and molecular evolution. Numerous algorithms and resources have been conceived to address this problem, but benchmarking and interpreting them is fraught with difficulties (need to compare them on a common input dataset, absence of ground truth, computational cost of calling orthologs). To address this, the Quest for Orthologs consortium maintains a reference set of proteomes and provides a web server for continuous orthology benchmarking (http://orthology.benchmarkservice.org). Furthermore, consensus ortholog calls derived from public benchmark submissions are provided on the Alliance of Genome Resources website, the joint portal of NIH-funded model organism databases.
Mots-clé
Animals, Benchmarking, Consensus, Genomics, Humans, Mice, Multigene Family, Phylogeny, Proteome, Rats, Software
Pubmed
Web of science
Open Access
Oui
Création de la notice
20/05/2020 8:25
Dernière modification de la notice
30/04/2021 7:16
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