Infectious diseases remain a significant cause of morbi-mortality in adults aged over 60 years, and many of these diseases are vaccine-preventable (VPDs). There is a pressing need to promote a lifelong vaccine schedule to increase vaccination against VPDs during the different stages of life. We outline the impact of vaccines on the burden of common infectious diseases and consider the negative clinical impact of VPDs in the unvaccinated population. We further illustrate that vaccine uptake is associated with a reduction in the burden of VPDs at any age of life, due to herd immunity. Disability-free and healthy aging is closely linked to childhood health and medical conditions in young adulthood. The midlife vaccine gap drastically impacts health in later life, especially in unvaccinated and older populations. These arguments underline the need for a preventive lifelong health perspective from childhood through old age.