MRS glucose mapping and PET joining forces: re-evaluation of the lumped constant in the rat brain under isoflurane anaesthesia.

Détails

ID Serval
serval:BIB_EBBAF92F5A77
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
MRS glucose mapping and PET joining forces: re-evaluation of the lumped constant in the rat brain under isoflurane anaesthesia.
Périodique
Journal of Neurochemistry
Auteur⸱e⸱s
Alf M.F., Duarte J.M., Lei H., Krämer S.D., Mlynarik V., Schibli R., Gruetter R.
ISSN
1471-4159 (Electronic)
ISSN-L
0022-3042
Statut éditorial
Publié
Date de publication
05/2014
Peer-reviewed
Oui
Volume
129
Numéro
4
Pages
672-682
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Although numerous positron emission tomography (PET) studies with (18) F-fluoro-deoxyglucose (FDG) have reported quantitative results on cerebral glucose kinetics and consumption, there is a large variation between the absolute values found in the literature. One of the underlying causes is the inconsistent use of the lumped constants (LCs), the derivation of which is often based on multiple assumptions that render absolute numbers imprecise and errors hard to quantify. We combined a kinetic FDG-PET study with magnetic resonance spectroscopic imaging (MRSI) of glucose dynamics in Sprague-Dawley rats to obtain a more comprehensive view of brain glucose kinetics and determine a reliable value for the LC under isoflurane anaesthesia. Maps of Tmax /CMRglc derived from MRSI data and Tmax determined from PET kinetic modelling allowed to obtain an LC-independent CMRglc . The LC was estimated to range from 0.33 ± 0.07 in retrosplenial cortex to 0.44 ± 0.05 in hippocampus, yielding CMRglc between 62 ± 14 and 54 ± 11 μmol/min/100 g, respectively. These newly determined LCs for four distinct areas in the rat brain under isoflurane anaesthesia provide means of comparing the growing amount of FDG-PET data available from translational studies.
Pubmed
Web of science
Open Access
Oui
Création de la notice
04/02/2014 7:26
Dernière modification de la notice
20/08/2019 16:13
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