Vasopressin in oligohydramnios-induced lung hypoplasia

Détails

ID Serval
serval:BIB_EB87A8C86F2A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Vasopressin in oligohydramnios-induced lung hypoplasia
Périodique
Pediatric Research
Auteur(s)
Shen  C. T., Moessinger  A. C., Kiu  G. T., James  L. S.
ISSN
0031-3998 (Print)
Statut éditorial
Publié
Date de publication
12/1990
Volume
28
Numéro
6
Pages
595-8
Notes
Journal Article --- Old month value: Dec
Résumé
Experimentally-induced oligohydramnios (oligo) produces lung hypoplasia. To determine if arginine vasopressin (AVP), a hormone known to decrease fetal lung fluid production, contributes to the pathogenesis of oligo-induced lung hypoplasia, the following experiment was performed. Brattleboro rats were mated to produce litters either with AVP [heterozygotes (HZ)] or without AVP [homozygotes (HO)]. On d 15 of gestation, half of each litter underwent amniocentesis to create persistent oligo. Littermates with intact membranes served as controls. Four groups of fetuses, i.e. 10 HO litters divided into control (44 fetuses) and oligo (25 fetuses), and eight HZ litters divided into control (35 fetuses) and oligo (18 fetuses), were killed at term for measurement of organ weights and biochemical determination of lung development. Significant differences between control and oligo groups were observed for body weight (HO, p = 0.008; HZ, p = 0.03), lung weight (less than 0.001 for both crossings), lung/body weight ratio (less than 0.001 for both), DNA per lung (HO, p = 0.02; HZ, p less than 0.001), and lung dry/wet ratio (HO, p less than 0.001; HZ, p = 0.001). Oligo groups with and without AVP were not found to be different for lung weight (p = 0.217), lung/body weight ratio (p = 0.209), and DNA per lung (p = 0.822). An analysis of variance confirmed the lack of any significant difference of the impact of oligo in the presence or absence of AVP. We conclude that AVP plays no role in the development of oligo-induced lung hypoplasia.
Mots-clé
Animals Arginine Vasopressin/deficiency/*physiology Body Fluids/physiology Disease Models, Animal Female Fetus/pathology/physiopathology Lung/*abnormalities/physiopathology Oligohydramnios/*complications Pregnancy Rats Rats, Brattleboro
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 13:16
Dernière modification de la notice
20/08/2019 16:13
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