Activation of MHC class I-restricted CD8+ CTL by microbial T cell mitogens. Dependence upon MHC class II expression of the target cells and V beta usage of the responder T cells

Détails

ID Serval
serval:BIB_EB3E0E1700DA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Activation of MHC class I-restricted CD8+ CTL by microbial T cell mitogens. Dependence upon MHC class II expression of the target cells and V beta usage of the responder T cells
Périodique
Journal of Immunology
Auteur⸱e⸱s
Herrmann  T., Maryanski  J. L., Romero  P., Fleischer  B., MacDonald  H. R.
ISSN
0022-1767 (Print)
Statut éditorial
Publié
Date de publication
02/1990
Volume
144
Numéro
4
Pages
1181-6
Notes
Journal Article --- Old month value: Feb 15
Résumé
The T cell response to microbial T cell mitogens (MTM) such as enterotoxins from Staphylococcus aureus (SE) and the soluble mitogen from Mycoplasma arthritidis, resemble the minor lymphocyte stimulatory locus (Mls) response in several aspects. An important feature of the Mls response is it restriction to CD4+ cells. This study demonstrates that in contrast to Mls, the MTM response includes both CD4+ and CD8+ subsets. Both CD4+ and CD8+ cells expanded in IL-2 after stimulation with SEB showed preferential expression of T cell receptors bearing V beta 8 domains. Mouse and human target cells could be lysed in the presence of MTM both by MTM-stimulated CD8+ lymphocytes and by MHC class I-restricted CTL clones of defined Ag specificity. MTM-induced lysis required the expression of MHC class II, but not class I Ag, on the target cells. Inhibition studies of SEB and Ag-dependent cytolysis by CTL clones underlined the crucial role of CD3 and LFA-1 in both instances, but showed CD8 dependence only for AG-dependent cytolysis. Together these findings suggest important differences between the putative MTM-mediated interaction of TCR with MHC molecules and the classical TCR/MHC interaction involved in MHC-restricted Ag recognition.
Mots-clé
Animals Antigens, CD3 Antigens, CD8 Antigens, Differentiation/analysis Antigens, Differentiation, T-Lymphocyte/analysis CD4-Positive T-Lymphocytes/immunology Cytotoxicity, Immunologic Enterotoxins/*pharmacology Histocompatibility Antigens Class I/immunology Histocompatibility Antigens Class II/immunology Lymphocyte Activation/*drug effects Lymphocyte Function-Associated Antigen-1 Mice Mice, Inbred Strains Mitogens Receptors, Antigen, T-Cell/analysis/*physiology Receptors, Antigen, T-Cell, alpha-beta Receptors, Leukocyte-Adhesion/analysis T-Lymphocytes, Cytotoxic/*immunology
Pubmed
Web of science
Création de la notice
28/01/2008 12:28
Dernière modification de la notice
20/08/2019 17:13
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