Circulating sex steroids during pregnancy and maternal risk of non-epithelial ovarian cancer.

Détails

Ressource 1Télécharger: BIB_EAABA3B5EE95.P001.pdf (693.00 [Ko])
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_EAABA3B5EE95
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Circulating sex steroids during pregnancy and maternal risk of non-epithelial ovarian cancer.
Périodique
Cancer Epidemiology, Biomarkers and Prevention
Auteur⸱e⸱s
Chen T., Surcel H.M., Lundin E., Kaasila M., Lakso H.A., Schock H., Kaaks R., Koskela P., Grankvist K., Hallmans G., Pukkala E., Zeleniuch-Jacquotte A., Toniolo P., Lehtinen M., Lukanova A.
ISSN
1538-7755 (Electronic)
ISSN-L
1055-9965
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
20
Numéro
2
Pages
324-336
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural
Résumé
BACKGROUND: Sex steroid hormones have been proposed to play a role in the development of non-epithelial ovarian cancers (NEOC) but so far no direct epidemiological data are available.METHODS: A case-control study was nested within the Finnish Maternity Cohort, the world's largest bio-repository of serum specimens from pregnant women. Study subjects were selected among women who donated a blood sample during a singleton pregnancy that led to the birth of their last child preceding diagnosis of NEOC. Case subjects were 41 women with sex-cord stromal tumors (SCST) and 21 with germ cell tumors (GCT). Three controls, matching the index case for age, parity at the index pregnancy, and date at blood donation were selected (n=171). Odds ratios (OR) and 95% confidence intervals (CI) associated with concentrations of testosterone, androstenedione, 17-OH-progesterone, progesterone, estradiol and sex hormone binding globulin (SHBG) were estimated through conditional logistic regression.RESULTS: For SCST, doubling of testosterone, androstenedione and 17-OH-progesterone concentrations were associated with about 2-fold higher risk of SCST [ORs and 95% CI of 2.16 (1.25-3.74), 2.16 (1.20-3.87), and 2.62 (1.27-5.38), respectively]. These associations remained largely unchanged after excluding women within 2, 4 or 6 years lag-time between blood donation and cancer diagnosis. Sex steroid hormones concentrations were not related to maternal risk of GCT.CONCLUSIONS: This is the first prospective study providing initial evidence that elevated androgens play a role in the pathogenesis of SCST. Impact: Our study may note a particular need for larger confirmatory investigations on sex steroids and NEOC.
Pubmed
Web of science
Open Access
Oui
Création de la notice
27/12/2010 14:22
Dernière modification de la notice
20/08/2019 16:13
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