Reactions and enzymes in the metabolism of drugs and other xenobiotics.
Détails
ID Serval
serval:BIB_EA7B63B171FE
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Reactions and enzymes in the metabolism of drugs and other xenobiotics.
Périodique
Drug Discovery Today
ISSN
1878-5832 (Electronic)
ISSN-L
1359-6446
Statut éditorial
Publié
Date de publication
2012
Volume
17
Numéro
11-12
Pages
549-560
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
In this article, we offer an overview of the compared quantitative importance of biotransformation reactions in the metabolism of drugs and other xenobiotics, based on a meta-analysis of current research interests. Also, we assess the relative significance the enzyme (super)families or categories catalysing these reactions. We put the facts unveiled by the analysis into a drug discovery context and draw some implications. The results confirm the primary role of cytochrome P450-catalysed oxidations and UDP-glucuronosyl-catalysed glucuronidations, but they also document the marked significance of several other reactions. Thus, there is a need for several drug discovery scientists to better grasp the variety of drug metabolism reactions and enzymes and their consequences.
Pubmed
Web of science
Création de la notice
29/06/2012 18:40
Dernière modification de la notice
20/08/2019 17:12