Reactions and enzymes in the metabolism of drugs and other xenobiotics.

Détails

ID Serval
serval:BIB_EA7B63B171FE
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Reactions and enzymes in the metabolism of drugs and other xenobiotics.
Périodique
Drug Discovery Today
Auteur⸱e⸱s
Testa B., Pedretti A., Vistoli G.
ISSN
1878-5832 (Electronic)
ISSN-L
1359-6446
Statut éditorial
Publié
Date de publication
2012
Volume
17
Numéro
11-12
Pages
549-560
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
In this article, we offer an overview of the compared quantitative importance of biotransformation reactions in the metabolism of drugs and other xenobiotics, based on a meta-analysis of current research interests. Also, we assess the relative significance the enzyme (super)families or categories catalysing these reactions. We put the facts unveiled by the analysis into a drug discovery context and draw some implications. The results confirm the primary role of cytochrome P450-catalysed oxidations and UDP-glucuronosyl-catalysed glucuronidations, but they also document the marked significance of several other reactions. Thus, there is a need for several drug discovery scientists to better grasp the variety of drug metabolism reactions and enzymes and their consequences.
Pubmed
Web of science
Création de la notice
29/06/2012 18:40
Dernière modification de la notice
20/08/2019 17:12
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