Primary systemic Sjögren syndrome (SS) preceding systemic lupus erythematosus: a retrospective study of 4 cases in a cohort of 55 SS patients.

Détails

ID Serval
serval:BIB_EA3C875D65B1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Primary systemic Sjögren syndrome (SS) preceding systemic lupus erythematosus: a retrospective study of 4 cases in a cohort of 55 SS patients.
Périodique
Lupus
Auteur⸱e⸱s
Zufferey P., Meyer O.C., Bourgeois P., Vayssairat M., Kahn M.F.
ISSN
0961-2033
Statut éditorial
Publié
Date de publication
1995
Peer-reviewed
Oui
Volume
4
Numéro
1
Pages
23-27
Langue
anglais
Notes
Publication types: Journal Article - Publication Status: ppublish
Résumé
That SS and SLE can coexist is well established. The time relationship between the two diseases is however not well known. To determine whether SS can precede SLE, we reviewed the charts of 55 patients with SS diagnosed in our department between 1975 and 1985. All 55 patients fulfilled at least four of the six preliminary criteria for SS developed by the European Study Group for SS. At entry, none met four ARA criteria for SLE and none had anti-double-stranded DNA or anti-Sm antibodies. The mean follow-up was 12 years (range 8-18 years). Four of the 55 patients developed SLE (7.5%). High titres of anti-native DNA antibodies (> 35 IU RIA, normal < 7 IU) appeared in four patients (2-11 years after the diagnosis of SS). Two of these patients fulfilled at least four ARA criteria for SLE; two others had only three criteria. Two additional patients developed anti-Sm antibodies without anti-native DNA antibodies 1 and 10 years after the initial diagnosis of SS, respectively. Both patients fulfilled six ARA criteria for SLE. At entry, anti-SSA and/or anti-SSB antibodies were present in all six SS patients and persisted subsequently. The main clinical events suggesting progression to SLE were pleuropericarditis, glomerulonephritis and focal central nervous system disease. In conclusion, SS with extraglandular components can antedate SLE by many years. Anti-native-DNA and anti-Sm antibodies should be measured when atypical clinical manifestations occur in a patient with systemic SS.
Mots-clé
Adult, Age of Onset, Autoantibodies, Cohort Studies, DNA, Follow-Up Studies, Humans, Lupus Erythematosus, Systemic, Retrospective Studies, Sjogren's Syndrome
Pubmed
Web of science
Création de la notice
25/03/2009 11:50
Dernière modification de la notice
20/08/2019 16:12
Données d'usage