The role of integrins in glioma biology and anti-glioma therapies.

Détails

ID Serval
serval:BIB_E90BAF906A3F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
The role of integrins in glioma biology and anti-glioma therapies.
Périodique
Current Pharmaceutical Design
Auteur⸱e⸱s
Tabatabai G., Tonn J.C., Stupp R., Weller M.
ISSN
1873-4286 (Electronic)
ISSN-L
1381-6128
Statut éditorial
Publié
Date de publication
2011
Volume
17
Numéro
23
Pages
2402-2410
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
The tumor environment is critical for tumor maintenance and progression. Integrins are a large family of cell surface receptors mediating the interaction of tumor cells with their microenvironment and play important roles in glioma biology, including migration, invasion, angiogenesis and tumor stem cell anchorage. Here, we review preclinical and clinical data on integrin inhibition in malignant gliomas. Various pharmacological approaches to the modulation of integrin signaling have been explored including antibodies and peptide-based agents. Cilengitide, a cyclic RGD-mimetic peptide of αvβ3 and αvβ5 integrins is in advanced clinical development in glioblastoma. Cilengitide had only limited activity as a single agent in glioblastoma, but, when added to standard radiochemotherapy, appeared to prolong progression-free and overall survival in patients with newly diagnosed glioblastomas and methylation of the promoter of the O⁶ methylguanine methyltransferase (MGMT) gene. MGMT gene promoter methylation in turn predicts benefit from alkylating chemotherapy. A phase III randomized clinical trial in conjunction with standard radiochemotherapy in newly diagnosed glioblastoma patients with MGMT gene promoter methylation has recently completed accrual (EORTC 26071-22072). A companion trial explores a dose-escalated regimen of cilengitide added to radiotherapy plus temozolomide in patients without MGMT gene promoter methylation. Promising results in these trials would probably result in a broader interest in integrins as targets for glioma therapy and hopefully the development of a broader panel of anti-integrin agents.
Pubmed
Web of science
Création de la notice
17/02/2012 22:37
Dernière modification de la notice
20/08/2019 17:11
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