Multicentric study on ¹⁸F-FDG-PET/CT breast incidental uptake in patients studied for non-breast malignant purposes.

Détails

ID Serval
serval:BIB_E8F8B797BB6E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Multicentric study on ¹⁸F-FDG-PET/CT breast incidental uptake in patients studied for non-breast malignant purposes.
Périodique
Revista espanola de medicina nuclear e imagen molecular
Auteur⸱e⸱s
Bertagna F., Evangelista L., Piccardo A., Bertoli M., Bosio G., Giubbini R., Orlando E., Treglia G.
ISSN
2253-8070 (Electronic)
ISSN-L
2253-654X
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
34
Numéro
1
Pages
24-29
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study
Publication Status: ppublish
Résumé
Our study has aimed to establish the prevalence and pathological nature of fluorine-18-fluorodeoxyglucose ((18)F-FDG) breast incidental uptake (BIU) in patients studied for non-malignant breast tumours and then to compare our data obtained in three Italian nuclear medicine centres with those available in literature.
We retrospectively evaluated 42,927 (18)F-FDG-PET/CT scans performed on patients studied in three Italian Nuclear Medicine Centres. All patients underwent (18)F-FDG-PET/CT for oncologic purposes not related to breast disease.
Among 42,927 scans, a BIU was identified in 79 (0.18%) patients, 75 (95%) female and 4 (5%) male with an average age of 62 ± 17 years. Twenty-five out of 35 (71.5%) BIUs were malignant and 10/35 (28.5%) benign. Among the 25/35 incidentalomas that were malignant, 12/25 (48%) were infiltrating ductal carcinoma, 5/25 (20%) ductal carcinoma (infiltrating and in situ), 4/25 (16%) lobular carcinoma, 2/25 (8%) ductal carcinoma in situ and 2/25 (8%) were metastases from the primary tumour under investigation. Of the 10 BIUs that were benign in the histological examination, after further investigations it was found that 9/10 (90%) were fibroadenomas and 1/10 (10%) was a benign lesion not better specified. The lesion to liver or to blood-pool SUVmax ratio in malignant lesions is significantly higher than in benign ones.
Our multicenter study demonstrates that, although they are uncommon, BIUs show a high percentage of malignancy and therefore requires further research.

Mots-clé
Adult, Aged, Aged, 80 and over, Breast Diseases/diagnostic imaging, Breast Diseases/epidemiology, Breast Neoplasms/chemistry, Breast Neoplasms/diagnostic imaging, Breast Neoplasms/epidemiology, Breast Neoplasms/secondary, Breast Neoplasms, Male/diagnostic imaging, Breast Neoplasms, Male/epidemiology, Carcinoma, Ductal, Breast/chemistry, Carcinoma, Ductal, Breast/diagnostic imaging, Carcinoma, Ductal, Breast/epidemiology, Carcinoma, Intraductal, Noninfiltrating/chemistry, Carcinoma, Intraductal, Noninfiltrating/diagnostic imaging, Carcinoma, Intraductal, Noninfiltrating/epidemiology, Carcinoma, Lobular/chemistry, Carcinoma, Lobular/diagnostic imaging, Carcinoma, Lobular/epidemiology, Female, Fibroadenoma/chemistry, Fibroadenoma/diagnostic imaging, Fibroadenoma/epidemiology, Fluorine Radioisotopes/pharmacokinetics, Fluorodeoxyglucose F18/pharmacokinetics, Humans, Incidental Findings, Italy, Male, Middle Aged, Neoplasms, Multiple Primary/chemistry, Neoplasms, Multiple Primary/diagnostic imaging, Neoplasms, Multiple Primary/epidemiology, Positron Emission Tomography Computed Tomography/methods, Radiopharmaceuticals/pharmacokinetics, Retrospective Studies, Tissue Distribution, (18)F-FDG, Breast, Incidentaloma, Mama, PET/CT, PET/TAC
Pubmed
Web of science
Création de la notice
20/08/2017 17:20
Dernière modification de la notice
20/08/2019 16:11
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