Caspofungin first-line therapy for invasive aspergillosis in allogeneic hematopoietic stem cell transplant patients: an European Organisation for Research and Treatment of Cancer study.

Détails

ID Serval
serval:BIB_E8DCDBA6F74E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Caspofungin first-line therapy for invasive aspergillosis in allogeneic hematopoietic stem cell transplant patients: an European Organisation for Research and Treatment of Cancer study.
Périodique
Bone Marrow Transplantation
Auteur⸱e⸱s
Herbrecht R., Maertens J., Baila L., Aoun M., Heinz W., Martino R., Schwartz S., Ullmann A.J., Meert L., Paesmans M., Marchetti O., Akan H., Ameye L., Shivaprakash M., Viscoli C.
ISSN
1476-5365[electronic], 0268-3369[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
45
Numéro
7
Pages
1227-1233
Langue
anglais
Résumé
Caspofungin at standard dose was evaluated as first-line monotherapy of mycologically documented probable/proven invasive aspergillosis (IA) (unmodified European Organisation for Research and Treatment of Cancer/Mycosis Study Group criteria) in allogeneic hematopoietic SCT patients. The primary efficacy end point was complete or partial response at end of caspofungin treatment. Response at week 12, survival and safety were additional end points. Enrollment was stopped prematurely because of low accrual, with 42 enrolled and 24 eligible, giving the study a power of 85%. Transplant was from unrelated donors in 16 patients; acute or chronic GVHD was present in 15. In all, 12 patients were neutropenic (<500/microl) at baseline, 10 received steroids and 16 calcineurin inhibitors or sirolimus. Median duration of caspofungin treatment was 24 days. At the end of caspofungin therapy, 10 (42%) patients had complete or partial response (95% confidence interval: 22-63%); 1 (4%) and 12 (50%) had stable and progressing disease, respectively; one was not evaluable. At week 12, eight patients (33%) had complete or partial response. Survival rates at week 6 and 12 were 79 and 50%, respectively. No patient had a drug-related serious adverse event or discontinued because of toxicity. Caspofungin first-line therapy was effective and well tolerated in allogeneic hematopoietic SCT patients with mycologically documented IA.
Mots-clé
Allogeneic, Aspergillosis, Caspofungin, Hematopoietic SCT, Liposomal Amphotericin-B, Fungal-Infections, Antifungal Therapy, Mold Infections, Risk-Factors, Recipients, Epidemiology, Efficacy, Safety, Voriconazole
Pubmed
Web of science
Open Access
Oui
Création de la notice
26/07/2010 10:26
Dernière modification de la notice
20/08/2019 16:11
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