Prognostic value of bronchoalveolar lavage fluid CD103+CD4+/CD4+ ratio in sarcoidosis
Détails
Etat: Public
Version: Après imprimatur
Licence: Non spécifiée
ID Serval
serval:BIB_E8B5A9C8EA74
Type
Mémoire
Sous-type
(Mémoire de) maîtrise (master)
Collection
Publications
Institution
Titre
Prognostic value of bronchoalveolar lavage fluid CD103+CD4+/CD4+ ratio in sarcoidosis
Directeur⸱rice⸱s
LAZOR R.
Codirecteur⸱rice⸱s
DACCORD C.
Détails de l'institution
Université de Lausanne, Faculté de biologie et médecine
Statut éditorial
Acceptée
Date de publication
2018
Langue
anglais
Nombre de pages
21
Résumé
The CD103+ integrin is an adhesion molecule found on > 95% of intra-epithelial mucosal lymphocytes, but on <2% of circulating lymphocytes. Several studies have shown that the proportion of CD4+ lymphocytes expressing the CD103+ integrin (CD103+CD4+/CD4+ ratio) in bronchoalveolar lavage fluid (BALF) was low in sarcoidosis compared to other interstitial lung diseases, but we previously demonstrated that the difference was insufficient to allow a confident diagnosis of sarcoidosis without tissue biopsy. Whether BALF CD103+CD4+/CD4+ ratio could have prognostic value in sarcoidosis is unknown. To address this issue, we examined the associations between BALF CD103+CD4+/CD4+ ratio and clinical and imaging characteristics in a retrospective series of 115 patients with sarcoidosis. 63% were men, with a median age of 48 years. 47% had radiographic stage I, 49% had stage II, and 4% had stage III or IV. The median BALF lymphocyte count was 43% and the median CD103+CD4+/CD4+ ratio was 17%. A higher CD103+CD4+/CD4+ ratio was significantly associated with a higher radiographic stage at diagnosis (p=0.017) and last visit (p<0.0001), as well as the presence of fibrosis at imaging at diagnosis (p=0.043) and last visit (p=0.032). Besides an inverse correlation with forced vital capacity at diagnosis (β=-0.16, p=0.031), no consistent association was found between the BALF CD103+CD4+/CD4+ ratio at diagnosis and lung function parameters at diagnosis and last visit. We conclude that BALF CD103+CD4+/CD4+ ratio may have prognostic value in sarcoidosis.
Mots-clé
CD103 integrin, CD103+CD4+/CD4+ ratio, Pronostic value, Bronchoalveolar lavage fluid, Sarcoidosis
Création de la notice
02/09/2019 15:45
Dernière modification de la notice
08/09/2020 7:11