Stable HIV-1 reservoirs on dolutegravir maintenance monotherapy: the MONODO study.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY-NC-ND 4.0
ID Serval
serval:BIB_E8A89170AD19
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Stable HIV-1 reservoirs on dolutegravir maintenance monotherapy: the MONODO study.
Périodique
HIV medicine
Auteur⸱e⸱s
Sculier D., Doco-Lecompte T., Yerly S., Metzner K.J., Decosterd L.A., Calmy A.
ISSN
1468-1293 (Electronic)
ISSN-L
1464-2662
Statut éditorial
Publié
Date de publication
22/06/2018
Peer-reviewed
Oui
Volume
19
Numéro
8
Pages
572-577
Langue
anglais
Notes
Publication types: Journal Article

Résumé
Dolutegravir (DTG) is a highly effective integrase inhibitor with a strong genetic resistance barrier and a potential role in simplified HIV maintenance treatment. We assessed the feasibility of DTG maintenance monotherapy and measured HIV reservoirs on DTG monotherapy.
An interventional, open-label, single-arm study including eight virologically suppressed HIV-1-infected patients switched to DTG 50 mg once daily for 24 weeks was performed. HIV-1 RNA levels in plasma and cerebrospinal and seminal fluids were measured at baseline and week 24, as well as HIV-1 DNA in peripheral cells and DTG concentrations in these compartments.
HIV-1 RNA remained undetectable in all samples of blood, cerebrospinal fluid and sperm throughout the 24 weeks, except for one cerebrospinal fluid sample with a value of 28 HIV-1 RNA copies/mL at week 24. One patient discontinued the study because of a neurological side effect. There was no change in the mean HIV-1 DNA level between baseline and week 24. Plasma and cerebrospinal fluid DTG concentrations reached therapeutic levels in all patients in these two compartments.
In this small sample of carefully selected patients, HIV-1 reservoirs were well controlled on DTG monotherapy over a period of 24 weeks. Viral suppression was also maintained throughout follow-up.
Mots-clé
HIV, HIV reservoirs, dolutegravir, maintenance therapy, simplification, HIV
Pubmed
Web of science
Open Access
Oui
Création de la notice
29/06/2018 16:53
Dernière modification de la notice
20/08/2019 16:11
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