Multiple control of N-acetylglutamate synthetase from Pseudomonas aeruginosa: synergistic inhibition by acetylglutamate and polyamines.

Détails

ID Serval
serval:BIB_E8A613BC0217
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Multiple control of N-acetylglutamate synthetase from Pseudomonas aeruginosa: synergistic inhibition by acetylglutamate and polyamines.
Périodique
Biochemical and Biophysical Research Communications
Auteur⸱e⸱s
Haas D., Leisinger T.
ISSN
0006-291X (Print)
ISSN-L
0006-291X
Statut éditorial
Publié
Date de publication
1974
Volume
60
Numéro
1
Pages
42-47
Langue
anglais
Résumé
N-Acetylglutamate synthetase (EC 2.3.1.1), the first enzyme of arginine synthesis was shown to be under multiple control by the reaction products and the endproducts of the pathway in tenfold purified extracts from . Synergistic inhibition of the enzyme was exerted by N-acetyl-L-glutamate and polyamines. At 0.5 mM N-acetyl-L-glutamate spermine was the most potent inhibitor, whereas spermidine, cadaverine and putrescine inhibited the enzyme to a lesser extent. Furthermore, feedback-inhibition by L-arginine was enhanced synergistically by N-acetyl-L-glutamate and CoA.
Mots-clé
Acetyl Coenzyme A, Acetyltransferases/antagonists & inhibitors, Arginine/pharmacology, Cadaverine/pharmacology, Carbon Radioisotopes, Coenzyme A, Diamines/pharmacology, Drug Synergism, Glutamates/pharmacology, Kinetics, Polyamines/pharmacology, Propane/analogs & derivatives, Propane/pharmacology, Pseudomonas aeruginosa/drug effects, Pseudomonas aeruginosa/enzymology, Putrescine/pharmacology, Spermidine/pharmacology, Spermine/pharmacology
Pubmed
Web of science
Création de la notice
25/01/2008 17:01
Dernière modification de la notice
20/08/2019 16:11
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