Hitting the Bullseye: Endogenous Electrophiles Show Remarkable Nuance in Signaling Regulation.

Détails

ID Serval
serval:BIB_E8A277D9440C
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Editorial
Collection
Publications
Institution
Titre
Hitting the Bullseye: Endogenous Electrophiles Show Remarkable Nuance in Signaling Regulation.
Périodique
Chemical research in toxicology
Auteur⸱e⸱s
Long MJC, Miranda Herrera P.A., Aye Y.
ISSN
1520-5010 (Electronic)
ISSN-L
0893-228X
Statut éditorial
Publié
Date de publication
17/10/2022
Peer-reviewed
Oui
Volume
35
Numéro
10
Pages
1636-1648
Langue
anglais
Notes
Publication types: Journal Article ; Review ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Our bodies produce a host of electrophilic species that can label specific endogenous proteins in cells. The signaling roles of these molecules are under active debate. However, in our opinion, it is becoming increasingly likely that electrophiles can rewire cellular signaling processes at endogenous levels. Attention is turning more to understanding how nuanced electrophile signaling in cells is. In this Perspective, we describe recent work from our laboratory that has started to inform on different levels of context-specific regulation of proteins by electrophiles. We discuss the relevance of these data to the field and to the broader application of electrophile signaling to precision medicine development, beyond the traditional views of their pleiotropic cytotoxic roles.
Mots-clé
Proteins/metabolism, Signal Transduction/physiology
Pubmed
Web of science
Création de la notice
25/04/2022 13:04
Dernière modification de la notice
05/10/2023 6:59
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