Hepatic arterial chemoembolization in the management of advanced digestive endocrine tumours.

Détails

ID Serval
serval:BIB_E8975D53AC07
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Hepatic arterial chemoembolization in the management of advanced digestive endocrine tumours.
Périodique
Italian Journal of Gastroenterology and Hepatology
Auteur⸱e⸱s
Dominguez S., Denys A., Menu Y., Ruszniewski P.
ISSN
1125-8055[print], 1125-8055[linking]
Statut éditorial
Publié
Date de publication
1999
Volume
31
Numéro
Suppl. 2
Pages
S213-S215
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Liver metastases, in patients with gastroenteropancreatic endocrine tumours, are present in 25-90%, depending on the nature of the primary tumour. Surgical resection is indicated only for localised liver metastasis, whereas in most cases with diffuse liver involvement other therapeutic modalities such as intravenous chemotherapy, embolization or hepatic arterial chemoembolization, ligation or intra-arterial chemotherapy are currently available. Hepatic arterial chemoembolization is specifically indicated for progressive tumours (mainly carcinoids) confined to the liver especially after unsuccessful systemic chemotherapy. A mixture of cytotoxic drug and iodised oil followed by gelatine sponge particles are injected in the branches of the hepatic artery supplying the tumours. 66-100% positive results of this treatment have been reported in the carcinoid syndrome with a 50-91% decrease in 5-HIAA secretion. Variation of tumour size (WHO criteria) has been reported in 33-80% of the cases, even if no direct comparison between chemoembolization and other therapeutic modalities are currently available. Extensive follow-up of the treated patients and additional studies will clarify the role of chemoembolisation in advanced digestive neuroendocrine tumours.
Mots-clé
Antineoplastic Combined Chemotherapy Protocols/administration & dosage, Carcinoid Tumor/mortality, Carcinoid Tumor/secondary, Chemoembolization, Therapeutic, Clinical Trials as Topic, Digestive System Neoplasms/mortality, Digestive System Neoplasms/pathology, Female, Hepatic Artery, Humans, Infusions, Intra-Arterial, Liver Neoplasms/mortality, Liver Neoplasms/secondary, Male, Prognosis, Severity of Illness Index, Survival Rate, Treatment Outcome
Pubmed
Web of science
Création de la notice
17/03/2010 10:30
Dernière modification de la notice
20/08/2019 17:11
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