High frequency of skin-homing melanocyte-specific cytotoxic T lymphocytes in autoimmune vitiligo

Détails

Ressource 1Télécharger: BIB_E88C57FF655C.P001.pdf (166.78 [Ko])
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_E88C57FF655C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
High frequency of skin-homing melanocyte-specific cytotoxic T lymphocytes in autoimmune vitiligo
Périodique
Journal of Experimental Medicine
Auteur⸱e⸱s
Ogg  G. S., Rod Dunbar  P., Romero  P., Chen  J. L., Cerundolo  V.
ISSN
0022-1007 (Print)
Statut éditorial
Publié
Date de publication
09/1998
Volume
188
Numéro
6
Pages
1203-8
Notes
Journal Article --- Old month value: Sep 21
Résumé
Vitiligo is an autoimmune condition characterized by loss of epidermal melanocytes. Using tetrameric complexes of human histocompatibility leukocyte antigen (HLA) class I to identify antigen-specific T cells ex vivo, we observed high frequencies of circulating MelanA-specific, A*0201-restricted cytotoxic T lymphocytes (A2-MelanA tetramer+ CTLs) in seven of nine HLA-A*0201-positive individuals with vitiligo. Isolated A2-MelanA tetramer+ CTLs were able to lyse A*0201-matched melanoma cells in vitro and their frequency ex vivo correlated with extent of disease. In contrast, no A2-MelanA tetramer+ CTL could be identified ex vivo in all four A*0201-negative vitiligo patients or five of six A*0201-positive asymptomatic controls. Finally, we observed that the A2-MelanA tetramer+ CTLs isolated from vitiligo patients expressed high levels of the skin homing receptor, cutaneous lymphocyte-associated antigen, which was absent from the CTLs seen in the single A*0201-positive normal control. These data are consistent with a role of skin-homing autoreactive melanocyte-specific CTLs in causing the destruction of melanocytes seen in autoimmune vitiligo. Lack of homing receptors on the surface of autoreactive CTLs could be a mechanism to control peripheral tolerance in vivo.
Mots-clé
Alleles Autoimmune Diseases/*immunology/pathology Cell Line Cell Movement/*immunology Cytotoxicity Tests, Immunologic HLA-A Antigens/genetics/immunology Humans Leukocytes, Mononuclear/chemistry Lymphocyte Activation Melanocytes/*immunology Melanoma Peptides/immunology Skin/*immunology/pathology T-Lymphocytes, Cytotoxic/*immunology/pathology Tumor Cells, Cultured Vitiligo/*immunology/pathology
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 11:28
Dernière modification de la notice
20/08/2019 16:11
Données d'usage